Who are Nirmatrelvir and ritonavir stage 1's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): PF-07321332 Dose 5, Paxlovid (Copackaged), Victrelis, Prezista, TIPRANAVIR, Reyataz.

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Last reviewed 2026-05-17 · How we verify

Nirmatrelvir and ritonavir stage 1 — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Nirmatrelvir and ritonavir stage 1 (Nirmatrelvir and ritonavir stage 1) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Protease inhibitor. Area: Infectious Disease / Virology.

marketed Protease inhibitor SARS-CoV-2 3CL protease (main protease) Infectious Disease / Virology Small molecule Live · refreshed every 30 min

Target snapshot

Nirmatrelvir and ritonavir stage 1 (Nirmatrelvir and ritonavir stage 1) — RenJi Hospital. Nirmatrelvir inhibits the SARS-CoV-2 main protease to prevent viral replication, while ritonavir boosts nirmatrelvir levels by inhibiting its metabolism.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Nirmatrelvir and ritonavir stage 1 TARGET	Nirmatrelvir and ritonavir stage 1	RenJi Hospital	marketed	Protease inhibitor	SARS-CoV-2 3CL protease (main protease)
PF-07321332 Dose 5	pf-07321332-dose-5	Pfizer	marketed	Protease inhibitor	Main protease (MPro) of SARS-CoV-2	Pending regulatory approval
Paxlovid (Copackaged)	Nirmatrelvir	Pfizer	marketed	Antiviral protease inhibitor	SARS-CoV-2 main protease (Mpro, 3CLpro, nsp5 protease)	2023-01-01
Victrelis	BOCEPREVIR	Merck & Co.	marketed	Hepatitis C Virus NS3/4A Protease Inhibitor	Chymase	2011-01-01
Prezista	DARUNAVIR	Janssen Prods	marketed	Protease Inhibitor [EPC]	Multidrug resistance protein 1	2006-01-01
TIPRANAVIR	TIPRANAVIR		marketed	Protease Inhibitor [EPC]		2005-01-01
Reyataz	ATAZANAVIR	Bristol-Myers Squibb	marketed	Protease Inhibitor	UDP-glucuronosyltransferase 1-1	2003-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2041-08-05 — Paxlovid (Copackaged) · 11351149 · US
2041-10-31 — Paxlovid (Copackaged) · 11541034 · US

Sponsor landscape (Protease inhibitor class)

Pfizer · 4 drugs in this class
French National Agency for Research on AIDS and Viral Hepatitis · 4 drugs in this class
Merck Sharp & Dohme LLC · 2 drugs in this class
Christopher J. McLeod · 1 drug in this class
Hoffmann-La Roche · 1 drug in this class
Janssen R&D Ireland · 1 drug in this class
Janssen-Cilag International NV · 1 drug in this class
Johns Hopkins University · 1 drug in this class
Medical Research Council · 1 drug in this class
Pfizer Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Nirmatrelvir and ritonavir stage 1 — Competitive Intelligence Brief. https://druglandscape.com/ci/nirmatrelvir-and-ritonavir-stage-1. Accessed 2026-05-17.

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