Who are NERATINIB's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Capecitabine combined with Pyrotinib, Dacomitinib (PF-00299804).

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

How do I get this as a recurring report?

Subscribe to /feed/ci/neratinib.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-13 · How we verify

NERATINIB — Competitive Intelligence Brief

NERATINIB (NERATINIB) competitive landscape: 2 comparators, recent regulatory actions, upcoming PDUFA, patent timeline.

marketed EGFR, HER2, HER4 Small molecule Live · refreshed every 30 min

Target snapshot

NERATINIB (NERATINIB). Neratinib irreversibly binds to EGFR, HER2, and HER4, reducing their autophosphorylation and downstream signaling, leading to antitumor activity.

Comparator set (2 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
NERATINIB TARGET	NERATINIB		marketed		EGFR, HER2, HER4	2017-01-01
Capecitabine combined with Pyrotinib	Capecitabine combined with Pyrotinib	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	phase 3	Combination chemotherapy and tyrosine kinase inhibitor	Thymidylate synthase (capecitabine); HER1/EGFR, HER2, HER4 (pyrotinib)
Dacomitinib (PF-00299804)	Dacomitinib (PF-00299804)	Pfizer	phase 3	Pan-HER tyrosine kinase inhibitor	EGFR, HER2, HER4

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape

No sponsor landscape data.

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Cite this brief

Drug Landscape (2026). NERATINIB — Competitive Intelligence Brief. https://druglandscape.com/ci/neratinib. Accessed 2026-05-13.

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