Who are Neoadjuvant ipilimumab + nivolumab's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Nivolumab in combination with Ipilimumab, AK102, Nivolumab & Ipilimumab, Adjuvant Nivolumab and Ipilimumab, APVO101, Fotemustine and Ipilimumab.

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Last reviewed 2026-05-18 · How we verify

Neoadjuvant ipilimumab + nivolumab — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Neoadjuvant ipilimumab + nivolumab (Neoadjuvant ipilimumab + nivolumab) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Immune checkpoint inhibitor combination. Area: Oncology.

phase 3 Immune checkpoint inhibitor combination PD-1 and CTLA-4 Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Neoadjuvant ipilimumab + nivolumab (Neoadjuvant ipilimumab + nivolumab) — The Netherlands Cancer Institute. This combination blocks two immune checkpoints (PD-1 and CTLA-4) to enhance anti-tumor immune responses before surgical resection.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Neoadjuvant ipilimumab + nivolumab TARGET	Neoadjuvant ipilimumab + nivolumab	The Netherlands Cancer Institute	phase 3	Immune checkpoint inhibitor combination	PD-1 and CTLA-4
Nivolumab in combination with Ipilimumab	Nivolumab in combination with Ipilimumab	Bristol-Myers Squibb	marketed	Checkpoint inhibitor combination (PD-1 inhibitor + CTLA-4 inhibitor)	PD-1 and CTLA-4
AK102	AK102	Akeso	phase 3	Bispecific checkpoint inhibitor	PD-1 and CTLA-4
Nivolumab & Ipilimumab	Nivolumab & Ipilimumab	The First Affiliated Hospital of Guangzhou Medical University	phase 3	PD-1 inhibitor + CTLA-4 inhibitor combination	PD-1 and CTLA-4
Adjuvant Nivolumab and Ipilimumab	Adjuvant Nivolumab and Ipilimumab	Universitätsklinikum Hamburg-Eppendorf	phase 3	PD-1 inhibitor and CTLA-4 inhibitor combination	PD-1 and CTLA-4
APVO101	APVO101	Medexus Pharma, Inc.	phase 3	Dual checkpoint inhibitor	PD-1 and CTLA-4
Fotemustine and Ipilimumab	Fotemustine and Ipilimumab	Italian Network for Tumor Biotherapy Foundation	phase 3	Chemotherapy + immune checkpoint inhibitor combination	DNA alkylation (fotemustine); CTLA-4 (ipilimumab)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Immune checkpoint inhibitor combination class)

The Netherlands Cancer Institute · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Neoadjuvant ipilimumab + nivolumab — Competitive Intelligence Brief. https://druglandscape.com/ci/neoadjuvant-ipilimumab-nivolumab. Accessed 2026-05-18.

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