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Naftifine Hydrochloride Cream 2% — Competitive Intelligence Brief
phase 3
Allylamine antifungal
Squalene epoxidase
Dermatology / Infectious Disease
Small molecule
Live · refreshed every 30 min
Target snapshot
Naftifine Hydrochloride Cream 2% (Naftifine Hydrochloride Cream 2%) — Sun Pharmaceutical Industries, Inc.. Naftifine is a fungistatic agent that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Naftifine Hydrochloride Cream 2% TARGET | Naftifine Hydrochloride Cream 2% | Sun Pharmaceutical Industries, Inc. | phase 3 | Allylamine antifungal | Squalene epoxidase | |
| Terbinafine Tablets | Terbinafine Tablets | Oregon Health and Science University | marketed | Allylamine antifungal | Squalene epoxidase | |
| Jublia® | Jublia® | Dong-A ST Co., Ltd. | marketed | Azole antifungal | Squalene epoxidase (fungal) | |
| Tavaborole 5% Topical Solution | Tavaborole 5% Topical Solution | Pfizer | marketed | Benzoxaborole antifungal | Squalene epoxidase | |
| NAFT500 (pediatric) | NAFT500 (pediatric) | Merz North America, Inc. | marketed | Allylamine antifungal | Squalene epoxidase | |
| NAFT600 (pediatric) | NAFT600 (pediatric) | Merz North America, Inc. | marketed | Topical antifungal (allylamine) | Squalene epoxidase (fungal) | |
| Lotrimin Ultra® | Lotrimin Ultra® | Sun Pharmaceutical Industries, Inc. | marketed | Allylamine antifungal | Squalene epoxidase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Allylamine antifungal class)
- Merz North America, Inc. · 3 drugs in this class
- Sun Pharmaceutical Industries, Inc. · 2 drugs in this class
- Bayer · 1 drug in this class
- Oregon Health and Science University · 1 drug in this class
- Pak Emirates Military Hospital · 1 drug in this class
- Novartis · 1 drug in this class
- Galderma R&D · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Naftifine Hydrochloride Cream 2% — Competitive Intelligence Brief. https://druglandscape.com/ci/naftifine-hydrochloride-cream-2. Accessed 2026-05-17.
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