Who are Praxilene's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Caplyta, Nuplazid, Latuda, Fanapt, Remeron, Effexor.

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Last reviewed 2026-06-10 · How we verify

Praxilene — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Praxilene (naftidrofuryl oxalate) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 5-HT2 receptor antagonist, Peripheral vasodilator. Area: Metabolic.

marketed 5-HT2 receptor antagonist, Peripheral vasodilator 5-hydroxytryptamine receptor 2A Metabolic Live · refreshed every 30 min

Target snapshot

Praxilene (naftidrofuryl oxalate) — Merck Serono (originally Lipha). A 5-HT2 receptor antagonist that improves peripheral blood flow and cellular metabolism by blocking serotonin-mediated vasoconstriction and enhancing aerobic metabolism in ischaemic tissues.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Praxilene TARGET	naftidrofuryl oxalate	Merck Serono (originally Lipha)	marketed	5-HT2 receptor antagonist, Peripheral vasodilator	5-hydroxytryptamine receptor 2A
Caplyta	LUMATEPERONE	Intra-Cellular	marketed	Atypical Antipsychotic [EPC]	5-hydroxytryptamine receptor 2A	2019-01-01
Nuplazid	PIMAVANSERIN	Acadia Pharms Inc	marketed	Atypical Antipsychotic	5-hydroxytryptamine receptor 2A	2016-01-01
Latuda	LURASIDONE	Sunovion Pharms Inc	marketed	Atypical Antipsychotic	5-hydroxytryptamine receptor 2A	2010-01-01
Fanapt	ILOPERIDONE	Vanda Pharms Inc	marketed	Atypical Antipsychotic [EPC]	5-hydroxytryptamine receptor 2A	2009-01-01
Remeron	mirtazapine	Generic (originally Organon/MSD)	marketed	NaSSA (Noradrenergic and specific serotonergic antidepressant)	5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C	1996-06-14
Effexor	venlafaxine	Generic (originally Wyeth/Pfizer)	marketed	SNRI (Serotonin-norepinephrine reuptake inhibitor)	5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C	1993-12-28

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (5-HT2 receptor antagonist, Peripheral vasodilator class)

Merck Serono (originally Lipha) · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Praxilene — Competitive Intelligence Brief. https://druglandscape.com/ci/naftidrofuryl-oxalate. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing