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MPL-001 (CBD: THC 25:1) — Competitive Intelligence Brief
phase 3
Cannabinoid combination
CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor
Small molecule
Live · refreshed every 30 min
Target snapshot
MPL-001 (CBD: THC 25:1) (MPL-001 (CBD: THC 25:1)) — McMaster University. MPL-001 is a cannabinoid combination product that modulates endocannabinoid signaling through CBD and THC at a 25:1 ratio to produce therapeutic effects.
Comparator set (5 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| MPL-001 (CBD: THC 25:1) TARGET | MPL-001 (CBD: THC 25:1) | McMaster University | phase 3 | Cannabinoid combination | CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor | |
| MediCabilis CBD Oil | MediCabilis CBD Oil | Gold Coast Hospital and Health Service | marketed | Cannabinoid | CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor (multiple targets) | |
| Cannabidiol (CBD) Oil Capsules | Cannabidiol (CBD) Oil Capsules | McMaster University | phase 3 | Phytocannabinoid | CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor (multi-target) | |
| Cannabidiol (CBD) Extract | Cannabidiol (CBD) Extract | Milton S. Hershey Medical Center | phase 3 | Cannabinoid receptor modulator | CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor | |
| Placebo Matched to Low-Dose Cannabidiol | Placebo Matched to Low-Dose Cannabidiol | Wayne State University | phase 3 | Cannabinoid | CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor | |
| Moderate-Dose Cannabidiol | Moderate-Dose Cannabidiol | Wayne State University | phase 3 | Cannabinoid | CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Cannabinoid combination class)
- McMaster University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). MPL-001 (CBD: THC 25:1) — Competitive Intelligence Brief. https://druglandscape.com/ci/mpl-001-cbd-thc-25-1. Accessed 2026-05-16.
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