Who are MPDL3280A's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): AVELUMAB, DURVALUMAB, Atezolizumab Injection [Tecentriq], Avelumab first-line maintenance, Pf-06823859, Pf-06865571.

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Last reviewed 2026-05-15 · How we verify

MPDL3280A — Competitive Intelligence Brief

MPDL3280A (MPDL3280A) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: PD-L1 inhibitor. Area: Oncology.

phase 3 PD-L1 inhibitor PD-L1 Oncology Small molecule Live · refreshed every 30 min

Target snapshot

MPDL3280A (MPDL3280A) — Clovis Oncology, Inc.. MPDL3280A is a monoclonal antibody that binds to PD-L1 and blocks its interaction with PD-1 and B7-1, thereby releasing the brakes on anti-tumor immune responses.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
MPDL3280A TARGET	MPDL3280A	Clovis Oncology, Inc.	phase 3	PD-L1 inhibitor	PD-L1
AVELUMAB	AVELUMAB		marketed	Programmed Death Ligand-1 Blocker [EPC]	PD-L1	2017-01-01
DURVALUMAB	DURVALUMAB		marketed	Programmed Death Ligand-1 Blocker [EPC]	PD-L1	2017-01-01
Atezolizumab Injection [Tecentriq]	Atezolizumab Injection [Tecentriq]	Nykode Therapeutics ASA	marketed	PD-L1 inhibitor	PD-L1
Avelumab first-line maintenance	Avelumab first-line maintenance	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	marketed	PD-L1 inhibitor	PD-L1
Pf-06823859	pf-06823859	Pfizer	marketed	Monoclonal Antibody	PD-1/PD-L1
Pf-06865571	pf-06865571	Pfizer	marketed	Monoclonal antibody	PD-1/PD-L1 pathway

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (PD-L1 inhibitor class)

Biocad · 13 drugs in this class
Shanghai Henlius Biotech · 8 drugs in this class
Celltrion · 5 drugs in this class
Mabwell (Shanghai) Bioscience Co., Ltd. · 4 drugs in this class
AstraZeneca · 4 drugs in this class
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. · 2 drugs in this class
Innovent Biologics (Suzhou) Co. Ltd. · 2 drugs in this class
Jiangsu HengRui Medicine Co., Ltd. · 2 drugs in this class
Shanghai Hengrui Pharmaceutical Co., Ltd. · 2 drugs in this class
CStone Pharmaceuticals · 1 drug in this class

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Cite this brief

Drug Landscape (2026). MPDL3280A — Competitive Intelligence Brief. https://druglandscape.com/ci/mpdl3280a. Accessed 2026-05-15.

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