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Mogamulizumab-Kpkc — Competitive Intelligence Brief
Target snapshot
Mogamulizumab-Kpkc (Mogamulizumab-Kpkc) — H. Lee Moffitt Cancer Center and Research Institute. 12.1 Mechanism of Action Mogamulizumab-kpkc is a defucosylated, humanized IgG1 kappa monoclonal antibody that binds to CCR4, a G protein-coupled receptor for CC chemokines that is involved in the trafficking of lymphocytes to various organs. Non-clinical in vitro studies demonstrate mogamulizumab-kpkc binding targets a cell for antibody-dependent cellular cytotoxicity (ADCC) resulting in depletion of the target cells. CCR4 is expressed on the surface of some T-cell malignancies and is expressed on regulatory T-cells (Treg) and a subset of Th2 T-cells.
Comparator set (4 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Mogamulizumab-Kpkc TARGET | Mogamulizumab-Kpkc | H. Lee Moffitt Cancer Center and Research Institute | discontinued | Chemokine Receptor Type 4 Interaction [EPC] | C-C chemokine receptor type 4 | |
| Poteligeo | MOGAMULIZUMAB | Kyowa Kirin | marketed | Chemokine Receptor Type 4 Interaction [EPC] | C-C chemokine receptor type 4 | 2018-01-01 |
| Poteligeo | Poteligeo | Kyowa Kirin Pharmaceutical Development Ltd | marketed | C-C chemokine receptor type 4 | ||
| MK-4280 | MK-4280 | Merck Sharp & Dohme LLC | phase 3 | CCR4 antagonist | CCR4 (C-C chemokine receptor type 4) | |
| MK-4280A | MK-4280A | Merck Sharp & Dohme LLC | phase 3 | CCR4 antagonist | CCR4 (C-C chemokine receptor type 4) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Chemokine Receptor Type 4 Interaction [EPC] class)
- H. Lee Moffitt Cancer Center and Research Institute · 1 drug in this class
- Kyowa Kirin · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Mogamulizumab-Kpkc — Competitive Intelligence Brief. https://druglandscape.com/ci/mogamulizumab-kpkc. Accessed 2026-05-17.
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