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Mogamulizumab-Kpkc — Competitive Intelligence Brief

Mogamulizumab-Kpkc (Mogamulizumab-Kpkc) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Chemokine Receptor Type 4 Interaction [EPC]. Area: Oncology.

discontinued Chemokine Receptor Type 4 Interaction [EPC] C-C chemokine receptor type 4 Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Mogamulizumab-Kpkc (Mogamulizumab-Kpkc) — H. Lee Moffitt Cancer Center and Research Institute. 12.1 Mechanism of Action Mogamulizumab-kpkc is a defucosylated, humanized IgG1 kappa monoclonal antibody that binds to CCR4, a G protein-coupled receptor for CC chemokines that is involved in the trafficking of lymphocytes to various organs. Non-clinical in vitro studies demonstrate mogamulizumab-kpkc binding targets a cell for antibody-dependent cellular cytotoxicity (ADCC) resulting in depletion of the target cells. CCR4 is expressed on the surface of some T-cell malignancies and is expressed on regulatory T-cells (Treg) and a subset of Th2 T-cells.

Comparator set (4 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Mogamulizumab-Kpkc TARGET Mogamulizumab-Kpkc H. Lee Moffitt Cancer Center and Research Institute discontinued Chemokine Receptor Type 4 Interaction [EPC] C-C chemokine receptor type 4
Poteligeo MOGAMULIZUMAB Kyowa Kirin marketed Chemokine Receptor Type 4 Interaction [EPC] C-C chemokine receptor type 4 2018-01-01
Poteligeo Poteligeo Kyowa Kirin Pharmaceutical Development Ltd marketed C-C chemokine receptor type 4
MK-4280 MK-4280 Merck Sharp & Dohme LLC phase 3 CCR4 antagonist CCR4 (C-C chemokine receptor type 4)
MK-4280A MK-4280A Merck Sharp & Dohme LLC phase 3 CCR4 antagonist CCR4 (C-C chemokine receptor type 4)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Chemokine Receptor Type 4 Interaction [EPC] class)

  1. H. Lee Moffitt Cancer Center and Research Institute · 1 drug in this class
  2. Kyowa Kirin · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Mogamulizumab-Kpkc — Competitive Intelligence Brief. https://druglandscape.com/ci/mogamulizumab-kpkc. Accessed 2026-05-17.

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