Who are MK-1084's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Akynzeo solution, fosnetupitant/ palonosetron, Aprepitant plus Ondansetron, Fosaprepitant for Injection, NOVA22007, Aprepitant plus Olanzapine.

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Last reviewed 2026-05-13 · How we verify

MK-1084 — Competitive Intelligence Brief

MK-1084 (MK-1084) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: NK1 receptor antagonist. Area: Pain management / Oncology supportive care.

phase 3 NK1 receptor antagonist NK1 receptor (neurokinin-1 receptor) Pain management / Oncology supportive care Small molecule Live · refreshed every 30 min

Target snapshot

MK-1084 (MK-1084) — Merck Sharp & Dohme LLC. MK-1084 is a selective antagonist of the neurokinin-1 (NK1) receptor that blocks substance P signaling in the central nervous system.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
MK-1084 TARGET	MK-1084	Merck Sharp & Dohme LLC	phase 3	NK1 receptor antagonist	NK1 receptor (neurokinin-1 receptor)
Akynzeo solution	Akynzeo solution	Helsinn Healthcare SA	marketed	NK1 receptor antagonist / 5-HT3 receptor antagonist combination	NK1 receptor (netupitant component); 5-HT3 receptor (palonosetron component)
fosnetupitant/ palonosetron	fosnetupitant/ palonosetron	Helsinn Healthcare SA	marketed	NK1 receptor antagonist / 5-HT3 receptor antagonist combination	NK1 receptor (substance P receptor) / 5-HT3 receptor
Aprepitant plus Ondansetron	Aprepitant plus Ondansetron	University of Pittsburgh	marketed	NK1 receptor antagonist + 5-HT3 receptor antagonist combination	NK1 receptor (aprepitant); 5-HT3 receptor (ondansetron)
Fosaprepitant for Injection	Fosaprepitant for Injection	Montefiore Medical Center	marketed	NK1 receptor antagonist	NK1 receptor (neurokinin-1 receptor)
NOVA22007	NOVA22007	Santen SAS	phase 3	NK1 receptor antagonist	NK1 receptor (neurokinin-1 receptor)
Aprepitant plus Olanzapine	Aprepitant plus Olanzapine	Rush University Medical Center	phase 3	NK1 receptor antagonist + atypical antipsychotic combination	Neurokinin-1 (NK1) receptor; dopamine D2 receptor; serotonin 5-HT2A receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (NK1 receptor antagonist class)

Merck Sharp & Dohme LLC · 4 drugs in this class
GlaxoSmithKline · 3 drugs in this class
Organon and Co · 3 drugs in this class
CCTU · 2 drugs in this class
Acacia Pharma Ltd · 2 drugs in this class
Sanofi · 1 drug in this class
Santen SAS · 1 drug in this class
CR-CSSS Champlain-Charles-Le Moyne · 1 drug in this class
Montefiore Medical Center · 1 drug in this class
New Mexico Cancer Research Alliance · 1 drug in this class

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Cite this brief

Drug Landscape (2026). MK-1084 — Competitive Intelligence Brief. https://druglandscape.com/ci/mk-1084. Accessed 2026-05-13.

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