Who are MK-0954A's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Aprepitant plus Ondansetron, Akynzeo solution, fosnetupitant/ palonosetron, Fosaprepitant for Injection, Experimental drug: Aprepitant, APD421.

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Last reviewed 2026-05-13 · How we verify

MK-0954A — Competitive Intelligence Brief

MK-0954A (MK-0954A) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: NK1 receptor antagonist. Area: Oncology; Pain Management.

phase 3 NK1 receptor antagonist NK1 receptor (neurokinin-1 receptor) Oncology; Pain Management Small molecule Live · refreshed every 30 min

Target snapshot

MK-0954A (MK-0954A) — Organon and Co. MK-0954A is a selective antagonist of the neurokinin-1 (NK1) receptor that blocks substance P signaling in the central nervous system.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
MK-0954A TARGET	MK-0954A	Organon and Co	phase 3	NK1 receptor antagonist	NK1 receptor (neurokinin-1 receptor)
Aprepitant plus Ondansetron	Aprepitant plus Ondansetron	University of Pittsburgh	marketed	NK1 receptor antagonist + 5-HT3 receptor antagonist combination	NK1 receptor (aprepitant); 5-HT3 receptor (ondansetron)
Akynzeo solution	Akynzeo solution	Helsinn Healthcare SA	marketed	NK1 receptor antagonist / 5-HT3 receptor antagonist combination	NK1 receptor (netupitant component); 5-HT3 receptor (palonosetron component)
fosnetupitant/ palonosetron	fosnetupitant/ palonosetron	Helsinn Healthcare SA	marketed	NK1 receptor antagonist / 5-HT3 receptor antagonist combination	NK1 receptor (substance P receptor) / 5-HT3 receptor
Fosaprepitant for Injection	Fosaprepitant for Injection	Montefiore Medical Center	marketed	NK1 receptor antagonist	NK1 receptor (neurokinin-1 receptor)
Experimental drug: Aprepitant	Experimental drug: Aprepitant	CCTU	phase 3	NK1 receptor antagonist	NK1 receptor (neurokinin-1 receptor)
APD421	APD421	Acacia Pharma Ltd	phase 3	NK1 receptor antagonist	NK1 receptor (neurokinin-1 receptor)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (NK1 receptor antagonist class)

Merck Sharp & Dohme LLC · 4 drugs in this class
GlaxoSmithKline · 3 drugs in this class
Organon and Co · 3 drugs in this class
CCTU · 2 drugs in this class
Acacia Pharma Ltd · 2 drugs in this class
Sanofi · 1 drug in this class
Santen SAS · 1 drug in this class
CR-CSSS Champlain-Charles-Le Moyne · 1 drug in this class
Montefiore Medical Center · 1 drug in this class
New Mexico Cancer Research Alliance · 1 drug in this class

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Cite this brief

Drug Landscape (2026). MK-0954A — Competitive Intelligence Brief. https://druglandscape.com/ci/mk-0954a. Accessed 2026-05-13.

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