Who are methotrexate prefilled syringe's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Trimethoprim, Gentamicin, Wellcovorin, Klaron, Sulfamethoxazole / Trimethoprim Injectable Product, TMX-SMX (Bactrim(R)).

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Last reviewed 2026-06-10 · How we verify

methotrexate prefilled syringe — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

methotrexate prefilled syringe (methotrexate prefilled syringe) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antimetabolite. Area: Oncology, Autoimmune diseases.

phase 3 Antimetabolite Dihydrofolate reductase Oncology, Autoimmune diseases Small molecule Live · refreshed every 30 min

Target snapshot

methotrexate prefilled syringe (methotrexate prefilled syringe) — medac GmbH. Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, disrupting DNA synthesis and cell division.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
methotrexate prefilled syringe TARGET	methotrexate prefilled syringe	medac GmbH	phase 3	Antimetabolite	Dihydrofolate reductase
Trimethoprim	TRIMETHOPRIM	Dr Reddys Labs Sa	marketed	Sulfonamide Antimicrobial [EPC]	Dihydrofolate reductase	1973-01-01
Gentamicin	Gentamicin Sulfate	Merck & Co.	marketed	gentamicin	Dihydrofolate reductase	1970-01-01
Wellcovorin	leucovorin	Pfizer Japan Inc	marketed	Folate Analog	Dihydrofolate reductase	1952-01-01
Klaron	SULFACETAMIDE	Merck & Co.	marketed	Sulfonamide Antibacterial	Dihydrofolate reductase	1945-01-01
Sulfamethoxazole / Trimethoprim Injectable Product	Sulfamethoxazole / Trimethoprim Injectable Product	Fundacion Clinic per a la Recerca Biomédica	marketed	Sulfonamide + dihydrofolate reductase inhibitor combination	Dihydropteroate synthase and dihydrofolate reductase
TMX-SMX (Bactrim(R))	TMX-SMX (Bactrim(R))	Department of Medical Services Ministry of Public Health of Thailand	marketed	Sulfonamide antibiotic combination	Dihydrofolate reductase; dihydropteroate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antimetabolite class)

Grupo Espanol Multidisciplinario del Cancer Digestivo · 2 drugs in this class
NRG Oncology · 2 drugs in this class
Bristol-Myers Squibb · 1 drug in this class
EMD Serono Research & Development Institute, Inc. · 1 drug in this class
GERCOR - Multidisciplinary Oncology Cooperative Group · 1 drug in this class
Hoffmann-La Roche · 1 drug in this class
Centre Oscar Lambret · 1 drug in this class
Iwate Medical University · 1 drug in this class
Janssen Research & Development, LLC · 1 drug in this class
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · 1 drug in this class

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Cite this brief

Drug Landscape (2026). methotrexate prefilled syringe — Competitive Intelligence Brief. https://druglandscape.com/ci/methotrexate-prefilled-syringe. Accessed 2026-06-10.

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