Who are Methotrexate (low dose)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Methotrexate (MTX), Methotrexate tablets, MTX therapy, MTX, Methotrexate Monotherapy, Methotrexate therapy.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Methotrexate (low dose) — Competitive Intelligence Brief

Methotrexate (low dose) (Methotrexate (low dose)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antimetabolite; folate antagonist. Area: Oncology; Immunology.

phase 3 Antimetabolite; folate antagonist Dihydrofolate reductase (DHFR) Oncology; Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Methotrexate (low dose) (Methotrexate (low dose)) — Case Comprehensive Cancer Center. Methotrexate is a folate antagonist that inhibits dihydrofolate reductase, blocking DNA synthesis and cell division in rapidly proliferating cells.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Methotrexate (low dose) TARGET	Methotrexate (low dose)	Case Comprehensive Cancer Center	phase 3	Antimetabolite; folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate (MTX)	Methotrexate (MTX)	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	marketed	Antimetabolite; folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate tablets	Methotrexate tablets	Yancheng First People's Hospital	marketed	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)
MTX therapy	MTX therapy	NYU Langone Health	marketed	Folate antagonist / Antimetabolite	Dihydrofolate reductase (DHFR)
MTX	MTX	South China Children's Leukemia Group	marketed	Antimetabolite; folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate Monotherapy	Methotrexate Monotherapy	Bangladesh Medical University	marketed	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate therapy	Methotrexate therapy	National Medical Research Center for Children's Health, Russian Federation	marketed	Folate antagonist / Antimetabolite	Dihydrofolate reductase (DHFR)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antimetabolite; folate antagonist class)

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · 1 drug in this class
Case Comprehensive Cancer Center · 1 drug in this class
Chonnam National University Hospital · 1 drug in this class
South China Children's Leukemia Group · 1 drug in this class
Sun Yat-sen University · 1 drug in this class
University Hospital, Montpellier · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Methotrexate (low dose) — Competitive Intelligence Brief. https://druglandscape.com/ci/methotrexate-low-dose. Accessed 2026-05-14.

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