Who are Provocholine's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Northera, Vesicare, Evoxac, Detrol, Atrovent, Carboxybenzylpenicillin.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

Provocholine — Competitive Intelligence Brief

Provocholine (METHACHOLINE) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Cholinergic Receptor Agonist. Area: Respiratory.

marketed Cholinergic Receptor Agonist Muscarinic acetylcholine receptor M1 Respiratory Small molecule Live · refreshed every 30 min

Target snapshot

Provocholine (METHACHOLINE) — Methapharm. Provocholine works by stimulating the M1 muscarinic acetylcholine receptor.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Provocholine TARGET	METHACHOLINE	Methapharm	marketed	Cholinergic Receptor Agonist	Muscarinic acetylcholine receptor M1	1986-01-01
Northera	DROXIDOPA	Lundbeck Na Ltd	marketed	Catecholamine	Muscarinic acetylcholine receptor M1	2014-01-01
Vesicare	SOLIFENACIN	Astellas Pharma	marketed	Cholinergic Muscarinic Antagonist	Muscarinic acetylcholine receptor M1	2004-01-01
Evoxac	CEVIMELINE	Cosette	marketed	Cholinergic Receptor Agonist	Muscarinic acetylcholine receptor M1	2000-01-01
Detrol	TOLTERODINE	Upjohn	marketed	Cholinergic Muscarinic Antagonist	Muscarinic acetylcholine receptor M1	1998-01-01
Atrovent	IPRATROPIUM		marketed	Anticholinergic	Muscarinic acetylcholine receptor M1	1986-01-01
Carboxybenzylpenicillin	CARBENICILLIN		marketed	Penicillin-class Antibacterial	Muscarinic acetylcholine receptor M1	1982-01-01

Recent regulatory actions (last 90 days)

2026-02-23 — Atrovent · FDA · approved · US

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Cholinergic Receptor Agonist class)

· 2 drugs in this class
Cosette · 1 drug in this class
Methapharm · 1 drug in this class
Pfizer · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Provocholine — Competitive Intelligence Brief. https://druglandscape.com/ci/methacholine. Accessed 2026-05-13.

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