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MEDI3250 — Competitive Intelligence Brief
phase 3
Bispecific antibody; PD-L1/4-1BB bispecific
PD-L1 and 4-1BB (CD137)
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
MEDI3250 (MEDI3250) — AstraZeneca. MEDI3250 is a bispecific antibody that simultaneously engages PD-L1 on tumor cells and 4-1BB on T cells to enhance anti-tumor immune responses.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| MEDI3250 TARGET | MEDI3250 | AstraZeneca | phase 3 | Bispecific antibody; PD-L1/4-1BB bispecific | PD-L1 and 4-1BB (CD137) | |
| Elrexfio | Elranatamab | Pfizer | marketed | Bispecific antibody | BCMA (B-cell maturation antigen) on plasma cells, plasmablasts, and multiple myeloma cells; CD3 on T-cells | 2023-01-01 |
| Elrexfio | elranatamab | Pfizer | marketed | Bispecific antibody | BCMA (B-cell maturation antigen) on plasma cells, plasmablasts, and multiple myeloma cells; CD3 on T-cells | 2023-01-01 |
| Elrantamab | elrantamab | Pfizer | marketed | Bispecific Antibody | BCMA (B-cell maturation antigen) | |
| HZT-501 | HZT-501 | Amgen | phase 3 | Bispecific antibody | ||
| BAT1706 | BAT1706 | Bio-Thera Solutions | phase 3 | Bispecific antibody; PD-1/TGF-β inhibitor | PD-1 and TGF-β | |
| BAT2206 | BAT2206 | Bio-Thera Solutions | phase 3 | Bispecific antibody; dual checkpoint inhibitor | Likely PD-1 and LAG-3 (or similar dual checkpoint targets) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Bispecific antibody; PD-L1/4-1BB bispecific class)
- AstraZeneca · 1 drug in this class
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- MEDI3250 CI watch — RSS
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- Whole Bispecific antibody; PD-L1/4-1BB bispecific class — RSS
Cite this brief
Drug Landscape (2026). MEDI3250 — Competitive Intelligence Brief. https://druglandscape.com/ci/medi3250. Accessed 2026-05-13.
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