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LV5FU2 or capecitabine — Competitive Intelligence Brief
phase 3
Fluoropyrimidine antimetabolite
Thymidylate synthase
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
LV5FU2 or capecitabine (LV5FU2 or capecitabine) — Federation Francophone de Cancerologie Digestive. LV5FU2/capecitabine is a fluoropyrimidine prodrug that inhibits thymidylate synthase and gets incorporated into DNA/RNA, disrupting cancer cell replication.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| LV5FU2 or capecitabine TARGET | LV5FU2 or capecitabine | Federation Francophone de Cancerologie Digestive | phase 3 | Fluoropyrimidine antimetabolite | Thymidylate synthase | |
| Xeloda | capecitabine | Cheplapharm | marketed | Nucleoside Metabolic Inhibitor [EPC] | Thymidylate synthase | 1998-01-01 |
| Fudr | FLOXURIDINE | marketed | Antimetabolite [EPC] | Thymidylate synthase | 1970-01-01 | |
| Folic Acid | FOLIC ACID | Pfizer | marketed | Vitamin C [EPC] | Thymidylate synthase | 1946-01-01 |
| Erlotinib, Pemetrexed | Erlotinib, Pemetrexed | Hunan Province Tumor Hospital | marketed | EGFR tyrosine kinase inhibitor + antifolate antimetabolite | EGFR; thymidylate synthase and folate-dependent enzymes | |
| Placebo plus S1 | Placebo plus S1 | Chinese PLA General Hospital | marketed | Fluoropyrimidine antimetabolite | Thymidylate synthase, dihydropyrimidine dehydrogenase | |
| 5Fluorouracil | 5Fluorouracil | University of Nebraska | marketed | Antimetabolite | Thymidylate synthase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Fluoropyrimidine antimetabolite class)
- Federation Francophone de Cancerologie Digestive · 2 drugs in this class
- National Cancer Center, Korea · 2 drugs in this class
- Hoffmann-La Roche · 1 drug in this class
- Japan Clinical Oncology Group · 1 drug in this class
- Jiangxi Provincial Cancer Hospital · 1 drug in this class
- Peter MacCallum Cancer Centre, Australia · 1 drug in this class
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · 1 drug in this class
- Taiho Pharmaceutical Co., Ltd. · 1 drug in this class
- The First Affiliated Hospital of Henan University of Science and Technology · 1 drug in this class
- UNICANCER · 1 drug in this class
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- LV5FU2 or capecitabine CI watch — RSS
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- LV5FU2 or capecitabine CI watch — JSON
- LV5FU2 or capecitabine alone — RSS
- Whole Fluoropyrimidine antimetabolite class — RSS
Cite this brief
Drug Landscape (2026). LV5FU2 or capecitabine — Competitive Intelligence Brief. https://druglandscape.com/ci/lv5fu2-or-capecitabine. Accessed 2026-05-17.
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