Who are lubiprostone (Amitiza)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Amitiza (Lubiprostone), Cohort 1: Lubiprostone Capsule, Fasted, Lubiprostone 24.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

lubiprostone (Amitiza) — Competitive Intelligence Brief

lubiprostone (Amitiza) (lubiprostone (Amitiza)) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: ClC-2 chloride channel activator. Area: Gastroenterology.

marketed ClC-2 chloride channel activator ClC-2 chloride channel Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

lubiprostone (Amitiza) (lubiprostone (Amitiza)) — Henry Ford Health System. Lubiprostone activates ClC-2 chloride channels in the intestinal epithelium to increase intestinal fluid secretion and promote bowel movements.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
lubiprostone (Amitiza) TARGET	lubiprostone (Amitiza)	Henry Ford Health System	marketed	ClC-2 chloride channel activator	ClC-2 chloride channel
Amitiza (Lubiprostone)	Amitiza (Lubiprostone)	Brooke Army Medical Center	marketed	Chloride channel activator	ClC-2 chloride channel
Cohort 1: Lubiprostone Capsule, Fasted	Cohort 1: Lubiprostone Capsule, Fasted	Sucampo Pharma Americas, LLC	phase 3	Chloride channel activator	ClC-2 chloride channel
Lubiprostone 24	Lubiprostone 24	Sucampo Pharma Americas, LLC	phase 3	ClC-2 chloride channel activator	ClC-2 chloride channel

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (ClC-2 chloride channel activator class)

Henry Ford Health System · 1 drug in this class
Sucampo Pharma Americas, LLC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). lubiprostone (Amitiza) — Competitive Intelligence Brief. https://druglandscape.com/ci/lubiprostone-amitiza. Accessed 2026-05-14.

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