Who are Low dose valproate's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Vorinostat (VOR), HIP2101, Ifupinostat Hydrochloride for Injection, SPARC0912, AL8326 tablets, MC0518.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Low dose valproate — Competitive Intelligence Brief

Low dose valproate (Low dose valproate) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Histone deacetylase (HDAC) inhibitor. Area: Oncology; Neurology; Immunology.

marketed Histone deacetylase (HDAC) inhibitor Histone deacetylases (HDACs) Oncology; Neurology; Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Low dose valproate (Low dose valproate) — Mario Negri Institute for Pharmacological Research. Low-dose valproate inhibits histone deacetylases (HDACs) and enhances histone acetylation, leading to altered gene expression and potential anti-inflammatory or anti-proliferative effects.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Low dose valproate TARGET	Low dose valproate	Mario Negri Institute for Pharmacological Research	marketed	Histone deacetylase (HDAC) inhibitor	Histone deacetylases (HDACs)
Vorinostat (VOR)	Vorinostat (VOR)	University of North Carolina, Chapel Hill	marketed	Histone deacetylase (HDAC) inhibitor	Histone deacetylases (HDAC1, HDAC2, HDAC3, HDAC6, HDAC8)
HIP2101	HIP2101	Hanmi Pharmaceutical Company Limited	phase 3	Histone deacetylase (HDAC) inhibitor	Histone deacetylase (HDAC)
Ifupinostat Hydrochloride for Injection	Ifupinostat Hydrochloride for Injection	BeBetter Med Inc	phase 3	Histone deacetylase (HDAC) inhibitor	Histone deacetylase (HDAC)
SPARC0912	SPARC0912	Sun Pharma Advanced Research Company Limited	phase 3	Histone deacetylase (HDAC) inhibitor	Histone deacetylase (HDAC)
AL8326 tablets	AL8326 tablets	Advenchen Laboratories Nanjing Ltd.	phase 3	Histone deacetylase (HDAC) inhibitor	Histone deacetylase (HDAC)
MC0518	MC0518	medac GmbH	phase 3	Histone deacetylase (HDAC) inhibitor	Histone deacetylase (HDAC)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Histone deacetylase (HDAC) inhibitor class)

Acrotech Biopharma Inc. · 1 drug in this class
Advenchen Laboratories Nanjing Ltd. · 1 drug in this class
BeBetter Med Inc · 1 drug in this class
Hanmi Pharmaceutical Company Limited · 1 drug in this class
Mario Negri Institute for Pharmacological Research · 1 drug in this class
Sun Pharma Advanced Research Company Limited · 1 drug in this class
University of North Carolina, Chapel Hill · 1 drug in this class
medac GmbH · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Low dose valproate — Competitive Intelligence Brief. https://druglandscape.com/ci/low-dose-valproate. Accessed 2026-05-14.

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