Who are Low Dose Hydroxyurea's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Gemzar, HYDROXYUREA, Gemcitabine Injectable Product, Gemcitabine-Cisplatin chemotherapy, Cladribine Tablets, Fludarabine (Flud).

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Low Dose Hydroxyurea — Competitive Intelligence Brief

Low Dose Hydroxyurea (Low Dose Hydroxyurea) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Ribonucleotide reductase inhibitor. Area: Hematology/Oncology.

phase 3 Ribonucleotide reductase inhibitor Ribonucleotide reductase Hematology/Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Low Dose Hydroxyurea (Low Dose Hydroxyurea) — Vanderbilt University Medical Center. Low-dose hydroxyurea increases fetal hemoglobin (HbF) production and reduces sickling of red blood cells by inhibiting ribonucleotide reductase.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Low Dose Hydroxyurea TARGET	Low Dose Hydroxyurea	Vanderbilt University Medical Center	phase 3	Ribonucleotide reductase inhibitor	Ribonucleotide reductase
Gemzar	Gemcitabine Hydrochloride	Accord Hlthcare	marketed	Nucleoside metabolic inhibitor	Ribonucleotide reductase; DNA incorporation	1996-01-01
HYDROXYUREA	HYDROXYUREA		marketed	Antimetabolite [EPC]	Ribonucleotide reductase	1967-01-01
Gemcitabine Injectable Product	Gemcitabine Injectable Product	Henan Cancer Hospital	marketed	Nucleoside analog antimetabolite	Ribonucleotide reductase; DNA incorporation
Gemcitabine-Cisplatin chemotherapy	Gemcitabine-Cisplatin chemotherapy	Simcere Pharmaceutical Co., Ltd	marketed	Chemotherapy combination (nucleoside analog + platinum agent)	DNA (multiple targets including ribonucleotide reductase inhibition and DNA cross-linking)
Cladribine Tablets	Cladribine Tablets	Keith Edwards, M.D.	marketed	Purine nucleoside analog	Ribonucleotide reductase; DNA incorporation
Fludarabine (Flud)	Fludarabine (Flud)	Technische Universität Dresden	marketed	Purine analog antimetabolite	Ribonucleotide reductase, DNA polymerase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2030-06-28 — Gemzar · 12403086 · Formulation · US
2032-04-15 — Gemzar · 8679094 · Formulation · US
2033-07-01 — Gemzar · 9241948 · Formulation · US
2034-08-19 — Gemzar · 10729823 · Formulation · US
2034-08-19 — Gemzar · 12447241 · Formulation · US
2041-12-23 — HYDROXYUREA · 12409156 · Formulation · US

Sponsor landscape (Ribonucleotide reductase inhibitor class)

Vanderbilt University Medical Center · 4 drugs in this class
Assistance Publique - Hôpitaux de Paris · 1 drug in this class
Suzhou Zelgen Biopharmaceuticals Co.,Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Low Dose Hydroxyurea — Competitive Intelligence Brief. https://druglandscape.com/ci/low-dose-hydroxyurea. Accessed 2026-05-14.

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