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low dose capecitabine — Competitive Intelligence Brief
phase 3
Antimetabolite
Thymidylate synthase
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
low dose capecitabine (low dose capecitabine) — Lund University Hospital. Capecitabine is a prodrug that is converted into 5-fluorouracil, which inhibits thymidylate synthase and disrupts DNA synthesis in cancer cells.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| low dose capecitabine TARGET | low dose capecitabine | Lund University Hospital | phase 3 | Antimetabolite | Thymidylate synthase | |
| Xeloda | capecitabine | Cheplapharm | marketed | Nucleoside Metabolic Inhibitor [EPC] | Thymidylate synthase | 1998-01-01 |
| Fudr | FLOXURIDINE | marketed | Antimetabolite [EPC] | Thymidylate synthase | 1970-01-01 | |
| Folic Acid | FOLIC ACID | Pfizer | marketed | Vitamin C [EPC] | Thymidylate synthase | 1946-01-01 |
| Erlotinib, Pemetrexed | Erlotinib, Pemetrexed | Hunan Province Tumor Hospital | marketed | EGFR tyrosine kinase inhibitor + antifolate antimetabolite | EGFR; thymidylate synthase and folate-dependent enzymes | |
| Unitrim | BRODIMOPRIM | marketed | brodimoprim | Bifunctional dihydrofolate reductase-thymidylate synthase, Dihydrofolate reductase | ||
| Irinotecan, 5FU, leucovorin | Irinotecan, 5FU, leucovorin | Asan Medical Center | marketed | Chemotherapy combination (topoisomerase I inhibitor + antimetabolite) | Topoisomerase I; thymidylate synthase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antimetabolite class)
- Grupo Espanol Multidisciplinario del Cancer Digestivo · 2 drugs in this class
- NRG Oncology · 2 drugs in this class
- Bristol-Myers Squibb · 1 drug in this class
- EMD Serono Research & Development Institute, Inc. · 1 drug in this class
- GERCOR - Multidisciplinary Oncology Cooperative Group · 1 drug in this class
- Hoffmann-La Roche · 1 drug in this class
- Centre Oscar Lambret · 1 drug in this class
- Iwate Medical University · 1 drug in this class
- Janssen Research & Development, LLC · 1 drug in this class
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · 1 drug in this class
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Cite this brief
Drug Landscape (2026). low dose capecitabine — Competitive Intelligence Brief. https://druglandscape.com/ci/low-dose-capecitabine. Accessed 2026-05-16.
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