Who are lopinavir/ritonavir (LPV/r)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Riv, Triple therapy with ritonavir, continue the PI/r-containing HAART., Tipranavir/Ritonavir, TMC114, TMC435.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-18 · How we verify

lopinavir/ritonavir (LPV/r) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

lopinavir/ritonavir (LPV/r) (lopinavir/ritonavir (LPV/r)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Protease inhibitor. Area: Infectious disease.

phase 3 Protease inhibitor HIV-1 protease Infectious disease Small molecule Live · refreshed every 30 min

Target snapshot

lopinavir/ritonavir (LPV/r) (lopinavir/ritonavir (LPV/r)) — French National Agency for Research on AIDS and Viral Hepatitis. Lopinavir/ritonavir is a protease inhibitor used to treat HIV-1 infection by preventing the replication of the virus.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
lopinavir/ritonavir (LPV/r) TARGET	lopinavir/ritonavir (LPV/r)	French National Agency for Research on AIDS and Viral Hepatitis	phase 3	Protease inhibitor	HIV-1 protease
Riv	riv	Pfizer	marketed	Protease Inhibitors	HIV-1 protease
Triple therapy with ritonavir	Triple therapy with ritonavir	Sociedad Andaluza de Enfermedades Infecciosas	marketed	HIV protease inhibitor	HIV-1 protease
continue the PI/r-containing HAART.	continue the PI/r-containing HAART.	ASST Fatebenefratelli Sacco	phase 3	Protease inhibitor	HIV-1 protease
Tipranavir/Ritonavir	Tipranavir/Ritonavir	Johns Hopkins University	phase 3	Protease inhibitor	HIV-1 protease
TMC114	TMC114	Tibotec Pharmaceuticals, Ireland	phase 3	protease inhibitor	HIV-1 protease
TMC435	TMC435	Tibotec Pharmaceuticals, Ireland	phase 3	protease inhibitor	HIV-1 protease

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Protease inhibitor class)

Pfizer · 4 drugs in this class
French National Agency for Research on AIDS and Viral Hepatitis · 4 drugs in this class
Merck Sharp & Dohme LLC · 2 drugs in this class
Christopher J. McLeod · 1 drug in this class
Hoffmann-La Roche · 1 drug in this class
Janssen R&D Ireland · 1 drug in this class
Janssen-Cilag International NV · 1 drug in this class
Johns Hopkins University · 1 drug in this class
Medical Research Council · 1 drug in this class
Pfizer Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). lopinavir/ritonavir (LPV/r) — Competitive Intelligence Brief. https://druglandscape.com/ci/lopinavir-ritonavir-lpv-r. Accessed 2026-05-18.

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