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Linagliptin / Metformin Oral Tablet — Competitive Intelligence Brief
marketed
DPP-4 inhibitor / Biguanide combination
DPP-4 (dipeptidyl peptidase-4) / AMPK pathway
Diabetes
Small molecule
Live · refreshed every 30 min
Target snapshot
Linagliptin / Metformin Oral Tablet (Linagliptin / Metformin Oral Tablet) — Universidad de Guanajuato. Linagliptin inhibits dipeptidyl peptidase-4 (DPP-4) to increase incretin levels, while metformin reduces hepatic glucose production and improves insulin sensitivity, together lowering blood glucose in type 2 diabetes.
Comparator set (2 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Linagliptin / Metformin Oral Tablet TARGET | Linagliptin / Metformin Oral Tablet | Universidad de Guanajuato | marketed | DPP-4 inhibitor / Biguanide combination | DPP-4 (dipeptidyl peptidase-4) / AMPK pathway | |
| Sitagliptin phosphate/metformin hydrochloride FDC | Sitagliptin phosphate/metformin hydrochloride FDC | Merck Sharp & Dohme LLC | marketed | DPP-4 inhibitor / biguanide combination | DPP-4 enzyme / metformin (AMPK pathway) | |
| Saxagliptin-Metformin XR | Saxagliptin-Metformin XR | Woman's | phase 3 | DPP-4 inhibitor / Biguanide combination | DPP-4 enzyme; metformin targets mitochondrial glycerophosphate dehydrogenase and AMPK |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (DPP-4 inhibitor / Biguanide combination class)
- Universidad de Guanajuato · 1 drug in this class
- Woman's · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Linagliptin / Metformin Oral Tablet — Competitive Intelligence Brief. https://druglandscape.com/ci/linagliptin-metformin-oral-tablet. Accessed 2026-05-17.
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