Who are Leucovorin/ levoleucovorin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Leucovorin (or Levoleucovorin).

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Leucovorin/ levoleucovorin — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Leucovorin/ levoleucovorin (Leucovorin/ levoleucovorin) competitive landscape: 1 comparator, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Folate analog / chemotherapy adjuvant. Area: Oncology.

phase 3 Folate analog / chemotherapy adjuvant Dihydrofolate reductase (bypass); tetrahydrofolate-dependent enzymes Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Leucovorin/ levoleucovorin (Leucovorin/ levoleucovorin) — Merck Sharp & Dohme LLC. Leucovorin and levoleucovorin are reduced forms of folic acid that enhance the activity of antimetabolite chemotherapy drugs by providing essential one-carbon units for nucleotide synthesis.

Comparator set (1 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Leucovorin/ levoleucovorin TARGET	Leucovorin/ levoleucovorin	Merck Sharp & Dohme LLC	phase 3	Folate analog / chemotherapy adjuvant	Dihydrofolate reductase (bypass); tetrahydrofolate-dependent enzymes
Leucovorin (or Levoleucovorin)	Leucovorin (or Levoleucovorin)	Merck Sharp & Dohme LLC	phase 3	Folate analog / Chemotherapy adjuvant	Dihydrofolate reductase (indirect); thymidylate synthase (potentiation)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Folate analog / chemotherapy adjuvant class)

Merck Sharp & Dohme LLC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Leucovorin/ levoleucovorin — Competitive Intelligence Brief. https://druglandscape.com/ci/leucovorin-levoleucovorin. Accessed 2026-05-16.

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