Who are Leucovorin/levofolinate calcium's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): PEMETREXED DIPOTASSIUM, Fusilev, Fusilev, Alimta, Wellcovorin, Leucovorin (or Levoleucovorin).

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Leucovorin/levofolinate calcium — Competitive Intelligence Brief

Leucovorin/levofolinate calcium (Leucovorin/levofolinate calcium) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Folate analog; chemotherapy adjuvant. Area: Oncology.

phase 3 Folate analog; chemotherapy adjuvant Thymidylate synthase (indirect); folate metabolism Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Leucovorin/levofolinate calcium (Leucovorin/levofolinate calcium) — Merck Sharp & Dohme LLC. Leucovorin is a reduced form of folic acid that replenishes intracellular folate pools and enhances the cytotoxic effects of fluorouracil and other antifolate drugs.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Leucovorin/levofolinate calcium TARGET	Leucovorin/levofolinate calcium	Merck Sharp & Dohme LLC	phase 3	Folate analog; chemotherapy adjuvant	Thymidylate synthase (indirect); folate metabolism
PEMETREXED DIPOTASSIUM	PEMETREXED DIPOTASSIUM		marketed	Folate Analog Metabolic Inhibitor [EPC]		2024-01-01
Fusilev	Levofolinic acid	Spectrum Pharms	marketed	Folate Analog		2008-01-01
Fusilev	levoleucovorin	Acrotech Biopharma	marketed	Folate Analog		2008-01-01
Alimta	pemetrexed	Actavis	marketed	Folate Analog Metabolic Inhibitor	Folate receptor alpha	2004-01-01
Wellcovorin	leucovorin	Pfizer Japan Inc	marketed	Folate Analog	Dihydrofolate reductase	1952-01-01
Leucovorin (or Levoleucovorin)	Leucovorin (or Levoleucovorin)	Merck Sharp & Dohme LLC	phase 3	Folate analog / Chemotherapy adjuvant	Dihydrofolate reductase (indirect); thymidylate synthase (potentiation)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2035-10-28 — Alimta · 9604990 · Compound · US
2036-02-19 — Alimta · 12115164 · Method of Use · US
2036-02-19 — Alimta · 11793813 · Formulation · US
2039-03-25 — Fusilev · 11541012 · US

Sponsor landscape (Folate analog; chemotherapy adjuvant class)

Merck Sharp & Dohme LLC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Leucovorin/levofolinate calcium — Competitive Intelligence Brief. https://druglandscape.com/ci/leucovorin-levofolinate-calcium. Accessed 2026-05-16.

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