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Lenalidomide/Low dose Dex — Competitive Intelligence Brief
phase 3
Immunomodulatory agent + corticosteroid combination
Cereblon (CRBN), TNF-α pathway, glucocorticoid receptor
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Lenalidomide/Low dose Dex (Lenalidomide/Low dose Dex) — King Faisal Specialist Hospital & Research Center. Lenalidomide enhances immune cell proliferation and anti-tumor activity while dexamethasone provides anti-inflammatory and anti-myeloma effects.
Comparator set (5 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Lenalidomide/Low dose Dex TARGET | Lenalidomide/Low dose Dex | King Faisal Specialist Hospital & Research Center | phase 3 | Immunomodulatory agent + corticosteroid combination | Cereblon (CRBN), TNF-α pathway, glucocorticoid receptor | |
| Drug: Carfilzomib + Lenalidomide + Dexamethasone | Drug: Carfilzomib + Lenalidomide + Dexamethasone | Amgen | marketed | Proteasome inhibitor + Immunomodulatory agent + Corticosteroid combination | 20S proteasome (carfilzomib); cereblon/CRBN (lenalidomide); glucocorticoid receptor (dexamethasone) | |
| VRD for first-cycle induction therapy | VRD for first-cycle induction therapy | The First Affiliated Hospital of Soochow University | marketed | Proteasome inhibitor + immunomodulatory agent + corticosteroid combination | 26S proteasome (bortezomib); cereblon/CRBN (lenalidomide); glucocorticoid receptor (dexamethasone) | |
| Carfilzomib Lenalidomide Dexamethasone | Carfilzomib Lenalidomide Dexamethasone | European Myeloma Network B.V. | phase 3 | Proteasome inhibitor + Immunomodulatory agent + Corticosteroid combination | 20S proteasome (carfilzomib); Cereblon/E3 ubiquitin ligase (lenalidomide); Glucocorticoid receptor (dexamethasone) | |
| Lenalidomide and Dexamethasone | Lenalidomide and Dexamethasone | HuniLife Biotechnology, Inc. | phase 3 | Immunomodulatory agent + corticosteroid combination | Cereblon (CRBN), TNF-α pathway; glucocorticoid receptor | |
| Bortezomib/Lenalidomide/ Low dose Dex | Bortezomib/Lenalidomide/ Low dose Dex | King Faisal Specialist Hospital & Research Center | phase 3 | Proteasome inhibitor + Immunomodulatory agent + Corticosteroid combination | Proteasome (bortezomib); Cereblon (lenalidomide); Glucocorticoid receptor (dexamethasone) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Immunomodulatory agent + corticosteroid combination class)
- HuniLife Biotechnology, Inc. · 1 drug in this class
- King Faisal Specialist Hospital & Research Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Lenalidomide/Low dose Dex — Competitive Intelligence Brief. https://druglandscape.com/ci/lenalidomide-low-dose-dex. Accessed 2026-06-10.
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