Who are JTE-451 Tablets's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): GW685698, OPC-6535 Tablets (drug), OPC-6535, GW406381.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

JTE-451 Tablets — Competitive Intelligence Brief

JTE-451 Tablets (JTE-451 Tablets) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: P2X7 receptor antagonist. Area: Immunology.

phase 2 P2X7 receptor antagonist P2X7 Immunology Small molecule Live · refreshed every 30 min

Target snapshot

JTE-451 Tablets (JTE-451 Tablets) — Akros Pharma Inc.. JTE-451 is a selective antagonist of the P2X7 receptor, which modulates immune cell activation and inflammatory responses.

Comparator set (4 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
JTE-451 Tablets TARGET	JTE-451 Tablets	Akros Pharma Inc.	phase 2	P2X7 receptor antagonist	P2X7
GW685698	GW685698	GlaxoSmithKline	phase 3	P2X7 receptor antagonist	P2X7
OPC-6535 Tablets (drug)	OPC-6535 Tablets (drug)	Otsuka Pharmaceutical Development & Commercialization, Inc.	phase 3	P2X7 receptor antagonist	P2X7
OPC-6535	OPC-6535	Otsuka Pharmaceutical Co., Ltd.	phase 3	P2X7 receptor antagonist	P2X7
GW406381	GW406381	GlaxoSmithKline	phase 3	P2X7 receptor antagonist	P2X7

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (P2X7 receptor antagonist class)

GlaxoSmithKline · 2 drugs in this class
Akros Pharma Inc. · 1 drug in this class
Otsuka Pharmaceutical Co., Ltd. · 1 drug in this class
Otsuka Pharmaceutical Development & Commercialization, Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). JTE-451 Tablets — Competitive Intelligence Brief. https://druglandscape.com/ci/jte-451-tablets. Accessed 2026-05-14.

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