Who are IPTp-sulphadoxine-pyrimethamine's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Sulfadoxine pyrimethamine, TMX-SMX (Bactrim(R)), Sulphadoxine-Pyrimethamine, Artesunate + Sulfadoxine-Pyrimethamine, Sulfadoxine-pyrimethamine/folic acid, Quinine plus sulfadoxine-pyrimethamine.

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Last reviewed 2026-05-17 · How we verify

IPTp-sulphadoxine-pyrimethamine — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

IPTp-sulphadoxine-pyrimethamine (IPTp-sulphadoxine-pyrimethamine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antifolate antimalarial combination. Area: Infectious Disease / Parasitology.

phase 3 Antifolate antimalarial combination Dihydrofolate reductase; Dihydropteroate synthase Infectious Disease / Parasitology Small molecule Live · refreshed every 30 min

Target snapshot

IPTp-sulphadoxine-pyrimethamine (IPTp-sulphadoxine-pyrimethamine) — London School of Hygiene and Tropical Medicine. Sulphadoxine-pyrimethamine is an antimalarial combination that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in Plasmodium parasites.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
IPTp-sulphadoxine-pyrimethamine TARGET	IPTp-sulphadoxine-pyrimethamine	London School of Hygiene and Tropical Medicine	phase 3	Antifolate antimalarial combination	Dihydrofolate reductase; Dihydropteroate synthase
Sulfadoxine pyrimethamine	Sulfadoxine pyrimethamine	Radboud University Medical Center	marketed	Antifolate antimalarial	Dihydrofolate reductase; dihydropteroate synthase
TMX-SMX (Bactrim(R))	TMX-SMX (Bactrim(R))	Department of Medical Services Ministry of Public Health of Thailand	marketed	Sulfonamide antibiotic combination	Dihydrofolate reductase; dihydropteroate synthase
Sulphadoxine-Pyrimethamine	Sulphadoxine-Pyrimethamine	ORIYOMI OMOTOYOSI AKINYOTU	marketed	Antifolate antimalarial	Dihydrofolate reductase; dihydropteroate synthase
Artesunate + Sulfadoxine-Pyrimethamine	Artesunate + Sulfadoxine-Pyrimethamine	Sanofi	marketed	Antimalarial combination	Plasmodium falciparum (multiple targets: artemisinin-induced oxidative stress; dihydrofolate reductase; dihydropteroate synthase)
Sulfadoxine-pyrimethamine/folic acid	Sulfadoxine-pyrimethamine/folic acid	Centers for Disease Control and Prevention	marketed	Antifolate antimalarial	Dihydrofolate reductase; dihydropteroate synthase
Quinine plus sulfadoxine-pyrimethamine	Quinine plus sulfadoxine-pyrimethamine	Albert Schweitzer Hospital	marketed	Antimalarial combination	Plasmodium DNA/protein synthesis; dihydrofolate reductase; dihydropteroate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antifolate antimalarial combination class)

London School of Hygiene and Tropical Medicine · 4 drugs in this class
Kenya Medical Research Institute · 1 drug in this class
Swiss Tropical & Public Health Institute · 1 drug in this class

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Cite this brief

Drug Landscape (2026). IPTp-sulphadoxine-pyrimethamine — Competitive Intelligence Brief. https://druglandscape.com/ci/iptp-sulphadoxine-pyrimethamine. Accessed 2026-05-17.

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