Who are Intrathecal Methotrexate's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Methotrexate therapy, Placebo Methotrexate, Methotrexate tablets, Methotrexate (stable dose), Methotrexate (MTX), MTX.

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Last reviewed 2026-06-10 · How we verify

Intrathecal Methotrexate — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intrathecal Methotrexate (Intrathecal Methotrexate) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antimetabolite; folate antagonist. Area: Oncology.

marketed Antimetabolite; folate antagonist Dihydrofolate reductase (DHFR) Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Intrathecal Methotrexate (Intrathecal Methotrexate) — Sun Yat-sen University. Intrathecal methotrexate is a chemotherapy agent delivered directly into the cerebrospinal fluid to inhibit dihydrofolate reductase and disrupt DNA synthesis in cancer cells, particularly those in the central nervous system.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Intrathecal Methotrexate TARGET	Intrathecal Methotrexate	Sun Yat-sen University	marketed	Antimetabolite; folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate therapy	Methotrexate therapy	National Medical Research Center for Children's Health, Russian Federation	marketed	Folate antagonist / Antimetabolite	Dihydrofolate reductase (DHFR)
Placebo Methotrexate	Placebo Methotrexate	AbbVie	marketed	Folate antagonist / Antimetabolite	Dihydrofolate reductase (DHFR)
Methotrexate tablets	Methotrexate tablets	Yancheng First People's Hospital	marketed	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate (stable dose)	Methotrexate (stable dose)	Hoffmann-La Roche	marketed	Antimetabolite; Folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate (MTX)	Methotrexate (MTX)	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	marketed	Antimetabolite; folate antagonist	Dihydrofolate reductase (DHFR)
MTX	MTX	South China Children's Leukemia Group	marketed	Antimetabolite; folate antagonist	Dihydrofolate reductase (DHFR)

Recent regulatory actions (last 90 days)

2026-04-15 — Methotrexate (MTX) · FDA · approved · US · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antimetabolite; folate antagonist class)

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · 1 drug in this class
Case Comprehensive Cancer Center · 1 drug in this class
Chonnam National University Hospital · 1 drug in this class
South China Children's Leukemia Group · 1 drug in this class
Sun Yat-sen University · 1 drug in this class
University Hospital, Montpellier · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Intrathecal Methotrexate — Competitive Intelligence Brief. https://druglandscape.com/ci/intrathecal-methotrexate. Accessed 2026-06-10.

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