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ICI35,868 (Diprivan) — Competitive Intelligence Brief
phase 3
Intravenous sedative-hypnotic
GABA-A receptor
Anesthesia
Small molecule
Live · refreshed every 30 min
Target snapshot
ICI35,868 (Diprivan) (ICI35,868 (Diprivan)) — AstraZeneca. Propofol is a rapid-acting intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| ICI35,868 (Diprivan) TARGET | ICI35,868 (Diprivan) | AstraZeneca | phase 3 | Intravenous sedative-hypnotic | GABA-A receptor | |
| Zulresso | BREXANOLONE | Sage Therap | marketed | Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator | GABA-A receptor alpha-1/beta-2/gamma-2 | 2019-01-01 |
| Onfi | CLOBAZAM | Lundbeck Pharms Llc | marketed | Benzodiazepine [EPC] | GABA-A receptor alpha-1/beta-2/gamma-2 | 2011-01-01 |
| Lusedra | FOSPROPOFOL | marketed | fospropofol | GABA-A receptor | 2008-01-01 | |
| Campral | ACAMPROSATE | Allergan/AbbVie | marketed | acamprosate | GABA-A receptor alpha-1/beta-3/gamma-2 | 2004-01-01 |
| Sonata | ZALEPLON | Pfizer | marketed | gamma-Aminobutyric Acid A Receptor Agonist [EPC] | GABA-A receptor alpha-1/beta-2/gamma-2 | 1999-01-01 |
| Suprane | DESFLURANE | Baxter | marketed | General Anesthetic [EPC] | GABA-A receptor; anion channel | 1992-01-01 |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
- — Onfi · 12403090 · Formulation · US
- — Onfi · 12290597 · Formulation · US
- — Onfi · 11541002 · Formulation · US
Sponsor landscape (Intravenous sedative-hypnotic class)
- AstraZeneca · 1 drug in this class
- Brugmann University Hospital · 1 drug in this class
- Centre Hospitalier Universitaire Dijon · 1 drug in this class
- Fayoum University Hospital · 1 drug in this class
- Iuliu Hatieganu University of Medicine and Pharmacy · 1 drug in this class
- RenJi Hospital · 1 drug in this class
- Second Affiliated Hospital, School of Medicine, Zhejiang University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). ICI35,868 (Diprivan) — Competitive Intelligence Brief. https://druglandscape.com/ci/ici35-868-diprivan. Accessed 2026-05-16.
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