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I-131 Iodocholesterol — Competitive Intelligence Brief
phase 3
Radiopharmaceutical
Adrenocortical tissue (cholesterol metabolism pathway)
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
I-131 Iodocholesterol (I-131 Iodocholesterol) — M.D. Anderson Cancer Center. I-131 Iodocholesterol is a radiolabeled cholesterol analog that localizes to adrenocortical tissue and delivers targeted radiation for imaging and therapeutic purposes in adrenocortical carcinoma.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| I-131 Iodocholesterol TARGET | I-131 Iodocholesterol | M.D. Anderson Cancer Center | phase 3 | Radiopharmaceutical | Adrenocortical tissue (cholesterol metabolism pathway) | |
| Dexamethasone plus Radium-223 | Dexamethasone plus Radium-223 | University Health Network, Toronto | marketed | Combination therapy: corticosteroid plus alpha-emitting radiopharmaceutical | Radium-223 targets calcium-mimetic bone uptake; dexamethasone targets glucocorticoid receptor | |
| Tc 99m filtered sulfur colloid | Tc 99m filtered sulfur colloid | Memorial Health University Medical Center | marketed | Radiopharmaceutical diagnostic agent | ||
| Fludeoxyglucose F 18 (FDG) | Fludeoxyglucose F 18 (FDG) | Teva Branded Pharmaceutical Products R&D, Inc. | marketed | Radiopharmaceutical; PET imaging agent | Glucose transporter (GLUT1); hexokinase | |
| Radium-223 | radium-223 | Pfizer | marketed | Radiopharmaceutical | Bone cells | |
| Ga-68-DOTATOC | Ga-68-DOTATOC | Weill Medical College of Cornell University | marketed | Radiopharmaceutical | Somatostatin receptors (SSTRs) on neuroendocrine tumor cells | |
| Technetium Tc99m Sestamibi | Technetium Tc99m Sestamibi | Lantheus Medical Imaging | marketed | Radiopharmaceutical imaging agent | Mitochondrial membrane potential |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Radiopharmaceutical class)
- Amsterdam UMC, location VUmc · 1 drug in this class
- Blue Earth Diagnostics · 1 drug in this class
- Brigham and Women's Hospital · 1 drug in this class
- Genzyme, a Sanofi Company · 1 drug in this class
- Gustave Roussy, Cancer Campus, Grand Paris · 1 drug in this class
- HTA Co., Ltd. · 1 drug in this class
- IRCCS San Raffaele · 1 drug in this class
- ITEL Telecomunicazioni Srl · 1 drug in this class
- M.D. Anderson Cancer Center · 1 drug in this class
- Michael C Roarke, MD · 1 drug in this class
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Cite this brief
Drug Landscape (2026). I-131 Iodocholesterol — Competitive Intelligence Brief. https://druglandscape.com/ci/i-131-iodocholesterol. Accessed 2026-05-14.
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