Who are Hydroxyurea treatment (HU)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Gemzar, HYDROXYUREA, Fludarabine (Bayer), Hydrea® (hydroxyurea ), Gemcitabine Injectable Product, Platinum + Gemcitabine.

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Last reviewed 2026-06-10 · How we verify

Hydroxyurea treatment (HU) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hydroxyurea treatment (HU) (Hydroxyurea treatment (HU)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Ribonucleotide reductase inhibitor. Area: Hematology/Oncology.

phase 3 Ribonucleotide reductase inhibitor Ribonucleotide reductase Hematology/Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Hydroxyurea treatment (HU) (Hydroxyurea treatment (HU)) — Assistance Publique - Hôpitaux de Paris. Hydroxyurea inhibits ribonucleotide reductase to reduce DNA synthesis and increase fetal hemoglobin production, reducing sickling and hemolysis.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Hydroxyurea treatment (HU) TARGET	Hydroxyurea treatment (HU)	Assistance Publique - Hôpitaux de Paris	phase 3	Ribonucleotide reductase inhibitor	Ribonucleotide reductase
Gemzar	Gemcitabine Hydrochloride	Accord Hlthcare	marketed	Nucleoside metabolic inhibitor	Ribonucleotide reductase; DNA incorporation	1996-01-01
HYDROXYUREA	HYDROXYUREA		marketed	Antimetabolite [EPC]	Ribonucleotide reductase	1967-01-01
Fludarabine (Bayer)	Fludarabine (Bayer)	Chinese PLA General Hospital	marketed	Purine analog antimetabolite	Ribonucleotide reductase, DNA polymerase
Hydrea® (hydroxyurea )	Hydrea® (hydroxyurea )	Assistance Publique - Hôpitaux de Paris	marketed	Antimetabolite; ribonucleotide reductase inhibitor	Ribonucleotide reductase
Gemcitabine Injectable Product	Gemcitabine Injectable Product	Henan Cancer Hospital	marketed	Nucleoside analog antimetabolite	Ribonucleotide reductase; DNA incorporation
Platinum + Gemcitabine	Platinum + Gemcitabine	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	marketed	Chemotherapy combination (platinum agent + nucleoside analog)	DNA (platinum crosslinking); ribonucleotide reductase and DNA polymerase (gemcitabine)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2030-06-28 — Gemzar · 12403086 · Formulation · US
2032-04-15 — Gemzar · 8679094 · Formulation · US
2033-07-01 — Gemzar · 9241948 · Formulation · US
2034-08-19 — Gemzar · 10729823 · Formulation · US
2034-08-19 — Gemzar · 12447241 · Formulation · US
2041-12-23 — HYDROXYUREA · 12409156 · Formulation · US

Sponsor landscape (Ribonucleotide reductase inhibitor class)

Vanderbilt University Medical Center · 4 drugs in this class
Assistance Publique - Hôpitaux de Paris · 1 drug in this class
Suzhou Zelgen Biopharmaceuticals Co.,Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Hydroxyurea treatment (HU) — Competitive Intelligence Brief. https://druglandscape.com/ci/hydroxyurea-treatment-hu. Accessed 2026-06-10.

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