Who are Hydroxyurea (Moderate Dose)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Gemzar, HYDROXYUREA, Fludarabine (FLU), Ara-C, Gemcitabine Injectable Product, Gemcitabine (GEM).

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Hydroxyurea (Moderate Dose) — Competitive Intelligence Brief

Hydroxyurea (Moderate Dose) (Hydroxyurea (Moderate Dose)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Ribonucleotide reductase inhibitor. Area: Hematology/Oncology.

phase 3 Ribonucleotide reductase inhibitor Ribonucleotide reductase Hematology/Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Hydroxyurea (Moderate Dose) (Hydroxyurea (Moderate Dose)) — Vanderbilt University Medical Center. Hydroxyurea inhibits ribonucleotide reductase to reduce DNA synthesis and promote fetal hemoglobin production.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Hydroxyurea (Moderate Dose) TARGET	Hydroxyurea (Moderate Dose)	Vanderbilt University Medical Center	phase 3	Ribonucleotide reductase inhibitor	Ribonucleotide reductase
Gemzar	Gemcitabine Hydrochloride	Accord Hlthcare	marketed	Nucleoside metabolic inhibitor	Ribonucleotide reductase; DNA incorporation	1996-01-01
HYDROXYUREA	HYDROXYUREA		marketed	Antimetabolite [EPC]	Ribonucleotide reductase	1967-01-01
Fludarabine (FLU)	Fludarabine (FLU)	Nanfang Hospital, Southern Medical University	marketed	Purine nucleoside analog	Ribonucleotide reductase, DNA polymerase
Ara-C	Ara-C	M.D. Anderson Cancer Center	marketed	Nucleoside analog, antimetabolite	DNA polymerase, ribonucleotide reductase
Gemcitabine Injectable Product	Gemcitabine Injectable Product	Henan Cancer Hospital	marketed	Nucleoside analog antimetabolite	Ribonucleotide reductase; DNA incorporation
Gemcitabine (GEM)	Gemcitabine (GEM)	Sun Yat-sen University	marketed	Nucleoside analog; antimetabolite	Ribonucleotide reductase; DNA polymerase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2030-06-28 — Gemzar · 12403086 · Formulation · US
2032-04-15 — Gemzar · 8679094 · Formulation · US
2033-07-01 — Gemzar · 9241948 · Formulation · US
2034-08-19 — Gemzar · 10729823 · Formulation · US
2034-08-19 — Gemzar · 12447241 · Formulation · US
2041-12-23 — HYDROXYUREA · 12409156 · Formulation · US

Sponsor landscape (Ribonucleotide reductase inhibitor class)

Vanderbilt University Medical Center · 4 drugs in this class
Assistance Publique - Hôpitaux de Paris · 1 drug in this class
Suzhou Zelgen Biopharmaceuticals Co.,Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Hydroxyurea (Moderate Dose) — Competitive Intelligence Brief. https://druglandscape.com/ci/hydroxyurea-moderate-dose. Accessed 2026-05-14.

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