Who are Hydroxyurea (Low Dose)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Gemzar, HYDROXYUREA, Cladribine Tablets, Fludarabine (FLU), Hydroxy Urea, Ara-C.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-15 · How we verify

Hydroxyurea (Low Dose) — Competitive Intelligence Brief

Hydroxyurea (Low Dose) (Hydroxyurea (Low Dose)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Ribonucleotide reductase inhibitor. Area: Hematology/Oncology.

phase 3 Ribonucleotide reductase inhibitor Ribonucleotide reductase Hematology/Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Hydroxyurea (Low Dose) (Hydroxyurea (Low Dose)) — Vanderbilt University Medical Center. Low-dose hydroxyurea increases fetal hemoglobin (HbF) production and reduces sickling of red blood cells by inhibiting ribonucleotide reductase.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Hydroxyurea (Low Dose) TARGET	Hydroxyurea (Low Dose)	Vanderbilt University Medical Center	phase 3	Ribonucleotide reductase inhibitor	Ribonucleotide reductase
Gemzar	Gemcitabine Hydrochloride	Accord Hlthcare	marketed	Nucleoside metabolic inhibitor	Ribonucleotide reductase; DNA incorporation	1996-01-01
HYDROXYUREA	HYDROXYUREA		marketed	Antimetabolite [EPC]	Ribonucleotide reductase	1967-01-01
Cladribine Tablets	Cladribine Tablets	Keith Edwards, M.D.	marketed	Purine nucleoside analog	Ribonucleotide reductase; DNA incorporation
Fludarabine (FLU)	Fludarabine (FLU)	Nanfang Hospital, Southern Medical University	marketed	Purine nucleoside analog	Ribonucleotide reductase, DNA polymerase
Hydroxy Urea	Hydroxy Urea	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	marketed	Antimetabolite	Ribonucleotide reductase
Ara-C	Ara-C	M.D. Anderson Cancer Center	marketed	Nucleoside analog, antimetabolite	DNA polymerase, ribonucleotide reductase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2030-06-28 — Gemzar · 12403086 · Formulation · US
2032-04-15 — Gemzar · 8679094 · Formulation · US
2033-07-01 — Gemzar · 9241948 · Formulation · US
2034-08-19 — Gemzar · 10729823 · Formulation · US
2034-08-19 — Gemzar · 12447241 · Formulation · US
2041-12-23 — HYDROXYUREA · 12409156 · Formulation · US

Sponsor landscape (Ribonucleotide reductase inhibitor class)

Vanderbilt University Medical Center · 4 drugs in this class
Assistance Publique - Hôpitaux de Paris · 1 drug in this class
Suzhou Zelgen Biopharmaceuticals Co.,Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Hydroxyurea (Low Dose) — Competitive Intelligence Brief. https://druglandscape.com/ci/hydroxyurea-low-dose. Accessed 2026-05-15.

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