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Hydrea® (hydroxyurea ) — Competitive Intelligence Brief
marketed
Antimetabolite; ribonucleotide reductase inhibitor
Ribonucleotide reductase
Oncology; Hematology
Small molecule
Live · refreshed every 30 min
Target snapshot
Hydrea® (hydroxyurea ) (Hydrea® (hydroxyurea )) — Assistance Publique - Hôpitaux de Paris. Hydroxyurea inhibits ribonucleotide reductase, reducing deoxyribonucleotide synthesis and slowing DNA replication in rapidly dividing cells.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Hydrea® (hydroxyurea ) TARGET | Hydrea® (hydroxyurea ) | Assistance Publique - Hôpitaux de Paris | marketed | Antimetabolite; ribonucleotide reductase inhibitor | Ribonucleotide reductase | |
| Gemzar | Gemcitabine Hydrochloride | Accord Hlthcare | marketed | Nucleoside metabolic inhibitor | Ribonucleotide reductase; DNA incorporation | 1996-01-01 |
| HYDROXYUREA | HYDROXYUREA | marketed | Antimetabolite [EPC] | Ribonucleotide reductase | 1967-01-01 | |
| Gemcitabine (GEM) | Gemcitabine (GEM) | Sun Yat-sen University | marketed | Nucleoside analog; antimetabolite | Ribonucleotide reductase; DNA polymerase | |
| Fludarabine (FLU) | Fludarabine (FLU) | Nanfang Hospital, Southern Medical University | marketed | Purine nucleoside analog | Ribonucleotide reductase, DNA polymerase | |
| Platinum + Gemcitabine | Platinum + Gemcitabine | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | marketed | Chemotherapy combination (platinum agent + nucleoside analog) | DNA (platinum crosslinking); ribonucleotide reductase and DNA polymerase (gemcitabine) | |
| Gemcitabine-Cisplatin chemotherapy | Gemcitabine-Cisplatin chemotherapy | Simcere Pharmaceutical Co., Ltd | marketed | Chemotherapy combination (nucleoside analog + platinum agent) | DNA (multiple targets including ribonucleotide reductase inhibition and DNA cross-linking) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
- — Gemzar · 12403086 · Formulation · US
- — Gemzar · 8679094 · Formulation · US
- — Gemzar · 9241948 · Formulation · US
- — Gemzar · 10729823 · Formulation · US
- — Gemzar · 12447241 · Formulation · US
- — HYDROXYUREA · 12409156 · Formulation · US
Sponsor landscape (Antimetabolite; ribonucleotide reductase inhibitor class)
- Assistance Publique - Hôpitaux de Paris · 1 drug in this class
- Bionoxx Inc. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Hydrea® (hydroxyurea ) — Competitive Intelligence Brief. https://druglandscape.com/ci/hydrea-hydroxyurea. Accessed 2026-05-14.
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