Who are Hormone replacement therapy's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): estradiol plus progesterone, Relugolix + Estradiol + Norethindrone Acetate, Armour Thyroid, EVOREL® CONTI, estradiol and progesterone, Conjugated equine estrogen topical cream.

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Last reviewed 2026-05-14 · How we verify

Hormone replacement therapy — Competitive Intelligence Brief

Hormone replacement therapy (Hormone replacement therapy) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Hormone replacement therapy. Area: Endocrinology / Women's Health.

marketed Hormone replacement therapy Estrogen receptor (ER-α, ER-β), Progesterone receptor (PR) Endocrinology / Women's Health Small molecule Live · refreshed every 30 min

Target snapshot

Hormone replacement therapy (Hormone replacement therapy) — Faculdade de Medicina do ABC. Hormone replacement therapy supplements deficient endogenous hormones (typically estrogen and/or progesterone) to alleviate symptoms of hormonal imbalance or deficiency.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Hormone replacement therapy TARGET	Hormone replacement therapy	Faculdade de Medicina do ABC	marketed	Hormone replacement therapy	Estrogen receptor (ER-α, ER-β), Progesterone receptor (PR)
estradiol plus progesterone	estradiol plus progesterone	Peking Union Medical College Hospital	marketed	Hormone replacement therapy (HRT)	Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ), Progesterone receptor (PR)
Relugolix + Estradiol + Norethindrone Acetate	Relugolix + Estradiol + Norethindrone Acetate	Sumitomo Pharma Switzerland GmbH	marketed	GnRH antagonist combination with hormone replacement therapy	GnRH receptor (relugolix component)
Armour Thyroid	Armour Thyroid	AbbVie	marketed	Thyroid hormone replacement therapy	Thyroid hormone receptors (TR-alpha and TR-beta)
EVOREL® CONTI	EVOREL® CONTI	Royal Brompton & Harefield NHS Foundation Trust	marketed	Hormone replacement therapy (HRT) — combined estrogen/progestin	Estrogen receptors (ER-α, ER-β) and progesterone receptor (PR)
estradiol and progesterone	estradiol and progesterone	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	marketed	Hormone replacement therapy (HRT)	Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ), Progesterone receptor (PR)
Conjugated equine estrogen topical cream	Conjugated equine estrogen topical cream	University of Louisville	marketed	Topical hormone replacement therapy; estrogen	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Hormone replacement therapy class)

Rabin Medical Center · 2 drugs in this class
Faculdade de Medicina do ABC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Hormone replacement therapy — Competitive Intelligence Brief. https://druglandscape.com/ci/hormone-replacement-therapy. Accessed 2026-05-14.

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