Who are GW406381's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): GW685698, OPC-6535 Tablets (drug), OPC-6535.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-15 · How we verify

GW406381 — Competitive Intelligence Brief

GW406381 (GW406381) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: P2X7 receptor antagonist. Area: Immunology / Neurology.

phase 3 P2X7 receptor antagonist P2X7 Immunology / Neurology Small molecule Live · refreshed every 30 min

Target snapshot

GW406381 (GW406381) — GlaxoSmithKline. GW406381 is a selective antagonist of the P2X7 receptor, an ATP-gated ion channel involved in inflammatory and immune responses.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
GW406381 TARGET	GW406381	GlaxoSmithKline	phase 3	P2X7 receptor antagonist	P2X7
GW685698	GW685698	GlaxoSmithKline	phase 3	P2X7 receptor antagonist	P2X7
OPC-6535 Tablets (drug)	OPC-6535 Tablets (drug)	Otsuka Pharmaceutical Development & Commercialization, Inc.	phase 3	P2X7 receptor antagonist	P2X7
OPC-6535	OPC-6535	Otsuka Pharmaceutical Co., Ltd.	phase 3	P2X7 receptor antagonist	P2X7

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (P2X7 receptor antagonist class)

GlaxoSmithKline · 2 drugs in this class
Akros Pharma Inc. · 1 drug in this class
Otsuka Pharmaceutical Co., Ltd. · 1 drug in this class
Otsuka Pharmaceutical Development & Commercialization, Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). GW406381 — Competitive Intelligence Brief. https://druglandscape.com/ci/gw406381. Accessed 2026-05-15.

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