Who are Guanfacine/Tenex's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lucemyra, Neurontin, Iopidine, Dipivefrin, Sudafed, Catapres-Tts-1.

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Last reviewed 2026-06-10 · How we verify

Guanfacine/Tenex — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Guanfacine/Tenex (Guanfacine/Tenex) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Alpha-2A adrenergic receptor agonist. Area: Psychiatry / Neurology.

marketed Alpha-2A adrenergic receptor agonist Alpha-2A adrenergic receptor Psychiatry / Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Guanfacine/Tenex (Guanfacine/Tenex) — Research Foundation for Mental Hygiene, Inc.. Guanfacine is an alpha-2A adrenergic receptor agonist that reduces norepinephrine release in the brain, decreasing sympathetic nervous system activity.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Guanfacine/Tenex TARGET	Guanfacine/Tenex	Research Foundation for Mental Hygiene, Inc.	marketed	Alpha-2A adrenergic receptor agonist	Alpha-2A adrenergic receptor
Lucemyra	LOFEXIDINE	Biocorrx Pharms	marketed	lofexidine	Alpha-2A adrenergic receptor	2018-01-01
Neurontin	gabapentin	Generic (originally Parke-Davis/Pfizer)	marketed	Gabapentinoid (anticonvulsant/neuropathic pain agent)	Large neutral amino acids transporter small subunit 1, Adenosine receptor A1, Alpha-2A adrenergic receptor	1993-12-30
Iopidine	APRACLONIDINE	Harrow Health	marketed	alpha-Adrenergic Agonist	Alpha-2A adrenergic receptor	1987-01-01
Dipivefrin	dipivefrine	AbbVie	marketed	Adrenergic Receptor Agonist	Alpha-2A adrenergic receptor	1980-01-01
Sudafed	pseudoephedrine	Generic (multiple manufacturers)	marketed	Nasal decongestant (sympathomimetic)	Alpha-1A adrenergic receptor, Alpha-2A adrenergic receptor, Beta-2 adrenergic receptor	1976-01-01
Catapres-Tts-1	CLONIDINE	Lavipharm	marketed	Central alpha-2 Adrenergic Agonist	Alpha-2A adrenergic receptor	1974-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2027-04-17 — Catapres-Tts-1 · 8337890 · Formulation · US
2031-09-08 — Catapres-Tts-1 · 8623409 · Formulation · US

Sponsor landscape (Alpha-2A adrenergic receptor agonist class)

Children's Hospital Medical Center, Cincinnati · 1 drug in this class
Neurology Group of Bergen County, P.A. · 1 drug in this class
Research Foundation for Mental Hygiene, Inc. · 1 drug in this class
Shire · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Guanfacine/Tenex — Competitive Intelligence Brief. https://druglandscape.com/ci/guanfacine-tenex. Accessed 2026-06-10.

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