Who are Amaryl's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Starlix, Glucotrol, Micronase, Proglycem, Dymelor, Aglicid.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

Amaryl — Competitive Intelligence Brief

Amaryl (GLIMEPIRIDE) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Sulfonylurea [EPC]. Area: Metabolic.

marketed Sulfonylurea [EPC] Sulfonylurea receptor 1, Kir6.2 Metabolic Small molecule Live · refreshed every 30 min

Target snapshot

Amaryl (GLIMEPIRIDE) — Sanofi. Amaryl works by binding to the sulfonylurea receptor 1 (SUR1) and Kir6.2 subunit of the ATP-sensitive potassium channel, closing the channel and depolarizing the pancreatic beta cell membrane, leading to insulin release.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Amaryl TARGET	GLIMEPIRIDE	Sanofi	marketed	Sulfonylurea [EPC]	Sulfonylurea receptor 1, Kir6.2	1995-01-01
Starlix	NATEGLINIDE	Novartis	marketed	Glinide [EPC]	Sulfonylurea receptor 1, Kir6.2	2000-01-01
Glucotrol	GLIPIZIDE	Pfizer	marketed	Sulfonylurea [EPC]	Sulfonylurea receptor 1, Kir6.2	1984-01-01
Micronase	glibenclamide	Sanofi	marketed	Sulfonylurea	Sulfonylurea receptor 1, Kir6.2	1984-01-01
Proglycem	DIAZOXIDE		marketed	diazoxide	Sulfonylurea receptor 1, Kir6.2	1973-01-01
Dymelor	ACETOHEXAMIDE	Eli Lilly	marketed	acetohexamide	Sulfonylurea receptor 1, Kir6.2	1964-01-01
Aglicid	TOLBUTAMIDE		marketed	Sulfonylurea	Sulfonylurea receptor 1, Kir6.2	1961-01-01

Recent regulatory actions (last 90 days)

2026-03-04 — Glucotrol · FDA · approved · US · Pfizer

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Sulfonylurea [EPC] class)

Pfizer · 1 drug in this class
Sanofi · 1 drug in this class
Takeda · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Amaryl — Competitive Intelligence Brief. https://druglandscape.com/ci/glimepiride. Accessed 2026-05-13.

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