Who are Gemcitabine + S-1's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Intensified chemotherapy, Fludarabine and Melphalan, FOLFOX/XELOX/Capecitabine.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-06-10 · How we verify

Gemcitabine + S-1 — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Gemcitabine + S-1 (Gemcitabine + S-1) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Cytotoxic chemotherapy combination. Area: Oncology.

phase 3 Cytotoxic chemotherapy combination Ribonucleotide reductase, DNA polymerase, thymidylate synthase Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Gemcitabine + S-1 (Gemcitabine + S-1) — AstraZeneca. Gemcitabine and S-1 are cytotoxic chemotherapy agents that work synergistically to inhibit DNA synthesis and cell division in cancer cells.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Gemcitabine + S-1 TARGET	Gemcitabine + S-1	AstraZeneca	phase 3	Cytotoxic chemotherapy combination	Ribonucleotide reductase, DNA polymerase, thymidylate synthase
Intensified chemotherapy	Intensified chemotherapy	Italian Sarcoma Group	phase 3	Cytotoxic chemotherapy combination
Fludarabine and Melphalan	Fludarabine and Melphalan	First Affiliated Hospital of Zhejiang University	phase 3	Cytotoxic chemotherapy combination (purine analog + alkylating agent)
FOLFOX/XELOX/Capecitabine	FOLFOX/XELOX/Capecitabine	Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine	phase 3	Cytotoxic chemotherapy combination regimen	Thymidylate synthase (5-FU component); DNA (oxaliplatin component)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Cytotoxic chemotherapy combination class)

AstraZeneca · 1 drug in this class
Italian Sarcoma Group · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Gemcitabine + S-1 — Competitive Intelligence Brief. https://druglandscape.com/ci/gemcitabine-s-1. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing