Fumaric acids — Competitive Intelligence Brief

Fumaric acids (Fumaric acids) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Immunomodulator. Area: Dermatology.

phase 2 Immunomodulator Dermatology Small molecule

Target snapshot

Fumaric acids (Fumaric acids) — Swiss Dermatology Network for Targeted Therapies. Fumaric acid is thought to modulate the immune system by inhibiting the production of pro-inflammatory cytokines.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Fumaric acids TARGET	Fumaric acids	Swiss Dermatology Network for Targeted Therapies	phase 2	Immunomodulator
Hydroxychloroquine reduced	Hydroxychloroquine reduced	University of Sao Paulo General Hospital	marketed	Antimalarial immunomodulator	Lysosomal function; TLR signaling
Hydroxychloroquine Sulfate Loading Dose	Hydroxychloroquine Sulfate Loading Dose	Government of Punjab, Specialized Healthcare and Medical Education Department	marketed	Antimalarial immunomodulator	Toll-like receptors (TLR), lysosomal pH modulation
Advanced Medical Therapy	Advanced Medical Therapy	Hadassah Medical Organization	marketed	Immunomodulator
Thymosin alpha1 & Pegylated Interferon-alpha2a	Thymosin alpha1 & Pegylated Interferon-alpha2a	Seoul National University Hospital	marketed	Immunomodulator combination	T-cell maturation pathway; interferon-alpha receptor (IFNAR)
TIMOFÉROL®	TIMOFÉROL®	Assistance Publique - Hôpitaux de Paris	marketed	Thymic extract / Immunomodulator
histamine dihydrochloride and IL-2	histamine dihydrochloride and IL-2	Cytovia, Inc.	marketed	Immunomodulator combination	Histamine receptors (H1, H2, H3, H4) and IL-2 receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Immunomodulator class)

1. Actavis Mid-Atlantic LLC · 1 drug in this class
2. Active Biotech AB · 1 drug in this class
3. Air Force Military Medical University, China · 1 drug in this class
4. Astellas Pharma Inc · 1 drug in this class
5. Bayer · 1 drug in this class
6. Beijing Children's Hospital · 1 drug in this class
7. Cancer Institute and Hospital, Chinese Academy of Medical Sciences · 1 drug in this class
8. Centro de Investigaciones Medicas y Ensayos Clinicos Dr Italo Fabbri · 1 drug in this class
9. Chang Gung Memorial Hospital · 1 drug in this class
10. ALK-Abelló A/S · 1 drug in this class