Who are evolocumab and LDL apheresis's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Repatha, Repatha®, Praluent (Alirocumab), Evolocumab Prefilled Syringe, LEQVIO, Evolocumab combined with statins.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

evolocumab and LDL apheresis — Competitive Intelligence Brief

evolocumab and LDL apheresis (evolocumab and LDL apheresis) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: PCSK9 inhibitor. Area: Cardiovascular.

phase 3 PCSK9 inhibitor PCSK9 Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

evolocumab and LDL apheresis (evolocumab and LDL apheresis) — Hospital General Universitario Gregorio Marañon. Evolocumab works by binding to PCSK9, a protein that regulates LDL cholesterol levels in the blood, thereby reducing LDL cholesterol production in the liver.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
evolocumab and LDL apheresis TARGET	evolocumab and LDL apheresis	Hospital General Universitario Gregorio Marañon	phase 3	PCSK9 inhibitor	PCSK9
Repatha	EVOLOCUMAB	Repatha	marketed	PCSK9 Inhibitor [EPC]	PCSK9	2015-01-01
Repatha®	Repatha®	Sejong General Hospital	marketed	PCSK9 inhibitor (monoclonal antibody)	PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9)
Praluent (Alirocumab)	Praluent (Alirocumab)	Federico II University	marketed	PCSK9 inhibitor (monoclonal antibody)	PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9)
Evolocumab Prefilled Syringe	Evolocumab Prefilled Syringe	University of Erlangen-Nürnberg Medical School	marketed	PCSK9 inhibitor (monoclonal antibody)	PCSK9
LEQVIO	LEQVIO	University of Louisville	marketed	PCSK9 inhibitor (siRNA)	PCSK9 mRNA
Evolocumab combined with statins	Evolocumab combined with statins	Zibo Central Hospital	marketed	PCSK9 inhibitor (monoclonal antibody)	PCSK9

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (PCSK9 inhibitor class)

Amgen · 4 drugs in this class
Bayer · 2 drugs in this class
Allergan · 2 drugs in this class
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. · 1 drug in this class
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III · 1 drug in this class
Hospital General Universitario Gregorio Marañon · 1 drug in this class
Novartis · 1 drug in this class
Shire · 1 drug in this class
Vincentage Pharma Co., Ltd · 1 drug in this class
Wolfson Medical Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). evolocumab and LDL apheresis — Competitive Intelligence Brief. https://druglandscape.com/ci/evolocumab-and-ldl-apheresis. Accessed 2026-05-16.

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