Last reviewed · How we verify
ethinyl estradiol + levonorgestrel + folic acid — Competitive Intelligence Brief
phase 3
Oral contraceptive with folic acid supplementation
Progesterone receptor, estrogen receptor
Contraception / Women's Health
Small molecule
Live · refreshed every 30 min
Target snapshot
ethinyl estradiol + levonorgestrel + folic acid (ethinyl estradiol + levonorgestrel + folic acid) — Galeno Desenvolvimento de Pesquisas Clínicas. This combination oral contraceptive suppresses ovulation through progestin and estrogen activity while folic acid supplementation reduces neural tube defect risk in pregnancy.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| ethinyl estradiol + levonorgestrel + folic acid TARGET | ethinyl estradiol + levonorgestrel + folic acid | Galeno Desenvolvimento de Pesquisas Clínicas | phase 3 | Oral contraceptive with folic acid supplementation | Progesterone receptor, estrogen receptor | |
| Drospirenone Ethinyl estradiol Myo-inositol | Drospirenone Ethinyl estradiol Myo-inositol | AGUNCO Obstetrics and Gynecology Centre | marketed | Oral contraceptive with insulin sensitizer | Progesterone receptor, estrogen receptor, inositol signaling pathway | |
| Kariva® | Kariva® | Teva Branded Pharmaceutical Products R&D, Inc. | marketed | Oral contraceptive (combined hormonal contraceptive) | Progesterone receptor, estrogen receptor | |
| Ortho Tri-Cyclen LO | Ortho Tri-Cyclen LO | Bristol-Myers Squibb | marketed | Oral contraceptive (combined hormonal contraceptive) | Progesterone receptor, estrogen receptor | |
| All participants (Aviane) | All participants (Aviane) | Oregon Health and Science University | marketed | Oral contraceptive (combined estrogen-progestin) | Progesterone receptor, estrogen receptor | |
| YAZ® | YAZ® | Teva Pharmaceuticals USA | marketed | Oral contraceptive (combined estrogen-progestin) | Progesterone receptor, estrogen receptor, mineralocorticoid receptor | |
| norelgestromin + ethinyl estradiol | norelgestromin + ethinyl estradiol | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | marketed | Combined oral contraceptive (progestin + estrogen) | Progesterone receptor, estrogen receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Oral contraceptive with folic acid supplementation class)
- Galeno Desenvolvimento de Pesquisas Clínicas · 1 drug in this class
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Cite this brief
Drug Landscape (2026). ethinyl estradiol + levonorgestrel + folic acid — Competitive Intelligence Brief. https://druglandscape.com/ci/ethinyl-estradiol-levonorgestrel-folic-acid. Accessed 2026-05-17.
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