Who are estradiol (Zesteem)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Orserdu, Nextstellis, Cerianna, Duavee, Osphena, Duavee.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-06-10 · How we verify

estradiol (Zesteem) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

estradiol (Zesteem) (estradiol (Zesteem)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: estrogen receptor agonist. Area: Women's Health.

phase 3 estrogen receptor agonist estrogen receptor Women's Health Small molecule Live · refreshed every 30 min

Target snapshot

estradiol (Zesteem) (estradiol (Zesteem)) — Renovo. Estradiol acts as an estrogen receptor agonist, mimicking the effects of the naturally occurring hormone estrogen in the body.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
estradiol (Zesteem) TARGET	estradiol (Zesteem)	Renovo	phase 3	estrogen receptor agonist	estrogen receptor
Orserdu	ELACESTRANT	Stemline Therap	marketed	Estrogen Receptor Antagonist [EPC]	Estrogen receptor	2023-01-01
Nextstellis	ESTETROL	Mayne Pharma	marketed	Estrogen	Estrogen receptor	2021-01-01
Cerianna	FLUOROESTRADIOL F-18	GE HealthCare	marketed	Radioactive Diagnostic Agent [EPC]	Estrogen receptor	2020-01-01
Duavee	conjugated-estrogens-bazedoxifene	Pfizer	marketed	Estrogen [EPC]	estrogen receptors α and β	2013-01-01
Osphena	OSPEMIFENE	Duchesnay	marketed	Estrogen Agonist/Antagonist [EPC]	Estrogen receptor beta	2013-01-01
Duavee	BAZEDOXIFENE	Wyeth Pharms Pfizer	marketed	Estrogen [EPC]	estrogen receptors (ER) α and β	2013-01-01

Recent regulatory actions (last 90 days)

2026-03-26 — Nextstellis · EMA · approved · EU · Mayne Pharma

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2027-03-10 — Duavee · 7683051 · US

Sponsor landscape (estrogen receptor agonist class)

Renovo · 1 drug in this class

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Cite this brief

Drug Landscape (2026). estradiol (Zesteem) — Competitive Intelligence Brief. https://druglandscape.com/ci/estradiol-zesteem. Accessed 2026-06-10.

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