Who are Estradiol vaginal cream's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Premarin, Premarin, Premarin, Premarin vaginal estrogen cream, Estrace 0.01% Vaginal Cream, Estrogen vaginal cream.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Estradiol vaginal cream — Competitive Intelligence Brief

Estradiol vaginal cream (Estradiol vaginal cream) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Estrogen replacement therapy. Area: Gynecology / Endocrinology.

marketed Estrogen replacement therapy Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) Gynecology / Endocrinology Small molecule Live · refreshed every 30 min

Target snapshot

Estradiol vaginal cream (Estradiol vaginal cream) — CONRAD. Estradiol vaginal cream delivers the hormone estradiol directly to vaginal tissues to restore local estrogen levels and relieve menopausal vaginal symptoms.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Estradiol vaginal cream TARGET	Estradiol vaginal cream	CONRAD	marketed	Estrogen replacement therapy	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
Premarin	Estrogens, Conjugated	Pfizer	marketed	Estrogen replacement therapy	Estrogen receptors (nuclear receptors)	1942-01-01
Premarin	Estrogens, Conjugated	Pfizer	marketed	Estrogen replacement therapy	Estrogen receptors (nuclear receptors)	1942-01-01
Premarin	Estrogens, Conjugated	Pfizer	marketed	Estrogen replacement therapy	Estrogen receptors (nuclear receptors)	1942-01-01
Premarin vaginal estrogen cream	Premarin vaginal estrogen cream	Medstar Health Research Institute	marketed	Estrogen replacement therapy (topical)	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
Estrace 0.01% Vaginal Cream	Estrace 0.01% Vaginal Cream	University of California, Irvine	marketed	Estrogen replacement therapy	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
Estrogen vaginal cream	Estrogen vaginal cream	The University of Texas Health Science Center, Houston	marketed	Estrogen replacement therapy (topical)	Estrogen receptor alpha and beta

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Estrogen replacement therapy class)

Pfizer · 3 drugs in this class
CONRAD · 1 drug in this class
Mylan Pharmaceuticals Inc · 1 drug in this class
University of California, Irvine · 1 drug in this class
University of Virginia · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Estradiol vaginal cream — Competitive Intelligence Brief. https://druglandscape.com/ci/estradiol-vaginal-cream. Accessed 2026-05-16.

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