Who are Estrace 0.01% Vaginal Cream's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Premarin, Premarin, Premarin, Estradiol vaginal cream, Estring Vaginal Product, Estradiol patch.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-17 · How we verify

Estrace 0.01% Vaginal Cream — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Estrace 0.01% Vaginal Cream (Estrace 0.01% Vaginal Cream) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Estrogen replacement therapy. Area: Gynecology / Endocrinology.

marketed Estrogen replacement therapy Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) Gynecology / Endocrinology Small molecule Live · refreshed every 30 min

Target snapshot

Estrace 0.01% Vaginal Cream (Estrace 0.01% Vaginal Cream) — University of California, Irvine. Estrace vaginal cream delivers estradiol directly to vaginal tissues to restore estrogen levels and relieve symptoms of vaginal atrophy and menopausal urogenital changes.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Estrace 0.01% Vaginal Cream TARGET	Estrace 0.01% Vaginal Cream	University of California, Irvine	marketed	Estrogen replacement therapy	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
Premarin	Estrogens, Conjugated	Pfizer	marketed	Estrogen replacement therapy	Estrogen receptors (nuclear receptors)	1942-01-01
Premarin	Estrogens, Conjugated	Pfizer	marketed	Estrogen replacement therapy	Estrogen receptors (nuclear receptors)	1942-01-01
Premarin	Estrogens, Conjugated	Pfizer	marketed	Estrogen replacement therapy	Estrogen receptors (nuclear receptors)	1942-01-01
Estradiol vaginal cream	Estradiol vaginal cream	CONRAD	marketed	Estrogen replacement therapy	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
Estring Vaginal Product	Estring Vaginal Product	University of California, Irvine	marketed	Estrogen replacement therapy (vaginal)	Estrogen receptor (ER-α and ER-β)
Estradiol patch	Estradiol patch	University of Virginia	marketed	Estrogen replacement therapy	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Estrogen replacement therapy class)

Pfizer · 3 drugs in this class
CONRAD · 1 drug in this class
Mylan Pharmaceuticals Inc · 1 drug in this class
University of California, Irvine · 1 drug in this class
University of Virginia · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Estrace 0.01% Vaginal Cream — Competitive Intelligence Brief. https://druglandscape.com/ci/estrace-0-01-vaginal-cream. Accessed 2026-05-17.

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