Who are Flolan's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Uptravi, Remodulin, Epalrestat,Mecobalamin, FLOLAN injection with reformulated diluent, Fundyl, Inhaled Epoprostenol and phenylephrine.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Flolan — Competitive Intelligence Brief

Flolan (EPOPROSTENOL) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Prostacycline Vasodilator [EPC]. Area: Cardiovascular.

marketed Prostacycline Vasodilator [EPC] Prostacyclin receptor Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Flolan (EPOPROSTENOL) — AstraZeneca. Flolan works by binding to the prostacyclin receptor, causing blood vessels to relax and dilate.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Flolan TARGET	EPOPROSTENOL	AstraZeneca	marketed	Prostacycline Vasodilator [EPC]	Prostacyclin receptor	1995-01-01
Uptravi	SELEXIPAG	AstraZeneca	marketed	Prostacyclin Receptor Agonist [EPC]	Prostacyclin receptor	2015-01-01
Remodulin	TREPROSTINIL	United Therap	marketed	Prostacycline Vasodilator [EPC]	Prostacyclin receptor	2002-01-01
Epalrestat,Mecobalamin	Epalrestat,Mecobalamin	Xiangya Hospital of Central South University	marketed	Prostacyclin analog + Cobalamin derivative combination	Prostacyclin receptor (IP receptor) + Methylcobalamin-dependent enzymes
FLOLAN injection with reformulated diluent	FLOLAN injection with reformulated diluent	GlaxoSmithKline	marketed	Prostacyclin analog	Prostacyclin receptor (IP receptor)
Fundyl	ENPROSTIL		marketed	enprostil	Prostacyclin receptor, Prostaglandin E2 receptor EP1 subtype, Prostaglandin E2 receptor EP3 subtype
Inhaled Epoprostenol and phenylephrine	Inhaled Epoprostenol and phenylephrine	University Health Network, Toronto	marketed	Prostacyclin analog with alpha-1 adrenergic agonist	Prostacyclin receptor (IP receptor); alpha-1 adrenergic receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Prostacycline Vasodilator [EPC] class)

AstraZeneca · 1 drug in this class
United Therap · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Flolan — Competitive Intelligence Brief. https://druglandscape.com/ci/epoprostenol. Accessed 2026-05-14.

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