Who are Dupilumab step-down's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Dupilumab (SAR231893), Dupilumab - Dose Reduction, Dupilumab Injectable Product, Depemokimab (GSK3511294), Placebo matching depemokimab.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Dupilumab step-down — Competitive Intelligence Brief

Dupilumab step-down (Dupilumab step-down) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: IL-4 receptor antagonist monoclonal antibody. Area: Immunology / Allergy / Dermatology.

marketed IL-4 receptor antagonist monoclonal antibody IL-4 receptor alpha (IL-4Rα) Immunology / Allergy / Dermatology Small molecule Live · refreshed every 30 min

Target snapshot

Dupilumab step-down (Dupilumab step-down) — Nantes University Hospital. Dupilumab is a monoclonal antibody that blocks the IL-4 receptor alpha subunit, inhibiting IL-4 and IL-13 signaling to reduce type 2 inflammatory responses.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Dupilumab step-down TARGET	Dupilumab step-down	Nantes University Hospital	marketed	IL-4 receptor antagonist monoclonal antibody	IL-4 receptor alpha (IL-4Rα)
Dupilumab (SAR231893)	Dupilumab (SAR231893)	Sanofi	marketed	IL-4 receptor antagonist monoclonal antibody	IL-4 receptor alpha (IL-4Rα)
Dupilumab - Dose Reduction	Dupilumab - Dose Reduction	Johns Hopkins University	marketed	IL-4 receptor antagonist monoclonal antibody	IL-4 receptor alpha (IL-4Rα)
Dupilumab Injectable Product	Dupilumab Injectable Product	University of Virginia	marketed	IL-4 receptor antagonist monoclonal antibody	IL-4 receptor alpha (IL-4Rα)
Depemokimab (GSK3511294)	Depemokimab (GSK3511294)	GlaxoSmithKline	phase 3	IL-4 receptor antagonist monoclonal antibody	IL-4Rα (Interleukin-4 receptor alpha)
Placebo matching depemokimab	Placebo matching depemokimab	GlaxoSmithKline	phase 3	IL-4 receptor antagonist monoclonal antibody	IL-4Rα (Interleukin-4 receptor alpha)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (IL-4 receptor antagonist monoclonal antibody class)

GlaxoSmithKline · 2 drugs in this class
Johns Hopkins University · 1 drug in this class
Nantes University Hospital · 1 drug in this class
Sanofi · 1 drug in this class
University of Virginia · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Dupilumab step-down — Competitive Intelligence Brief. https://druglandscape.com/ci/dupilumab-step-down. Accessed 2026-05-16.

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