Who are DPP-4 inhibitor (sitagliptin)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Metformin and Saxagliptin, SGLT2i+Metformin+Cofrogliptin, Teneli (Teneligliptin), Januvia (sitagliptin), MET + Vildagliptin Group, DPP-4 inhibitor + metformin group.

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Last reviewed 2026-05-17 · How we verify

DPP-4 inhibitor (sitagliptin) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

DPP-4 inhibitor (sitagliptin) (DPP-4 inhibitor (sitagliptin)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: DPP-4 inhibitor. Area: Diabetes.

phase 3 DPP-4 inhibitor DPP-4 (dipeptidyl peptidase-4) Diabetes Small molecule Live · refreshed every 30 min

Target snapshot

DPP-4 inhibitor (sitagliptin) (DPP-4 inhibitor (sitagliptin)) — GRADE Study Group. Sitagliptin inhibits dipeptidyl peptidase-4 (DPP-4), an enzyme that breaks down incretin hormones, thereby increasing insulin secretion and reducing glucagon in response to meals.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
DPP-4 inhibitor (sitagliptin) TARGET	DPP-4 inhibitor (sitagliptin)	GRADE Study Group	phase 3	DPP-4 inhibitor	DPP-4 (dipeptidyl peptidase-4)
Metformin and Saxagliptin	Metformin and Saxagliptin	ikfe-CRO GmbH	marketed	Biguanide + DPP-4 inhibitor combination	Metformin: mitochondrial glycerophosphate dehydrogenase; Saxagliptin: DPP-4 (dipeptidyl peptidase-4)
SGLT2i+Metformin+Cofrogliptin	SGLT2i+Metformin+Cofrogliptin	Huazhong University of Science and Technology	marketed	SGLT2 inhibitor + Biguanide + DPP-4 inhibitor (fixed-dose combination)	SGLT2, mitochondrial complex I, DPP-4
Teneli (Teneligliptin)	Teneli (Teneligliptin)	Tanabe Pharma Corporation	marketed	DPP-4 inhibitor	DPP-4 (Dipeptidyl peptidase-4)
Januvia (sitagliptin)	Januvia (sitagliptin)	Zealand University Hospital	marketed	DPP-4 inhibitor	DPP-4 (dipeptidyl peptidase-4)
MET + Vildagliptin Group	MET + Vildagliptin Group	Hospital de Clinicas de Porto Alegre	marketed	Combination antidiabetic agent (biguanide + DPP-4 inhibitor)	Metformin: mitochondrial glycerophosphate dehydrogenase; Vildagliptin: DPP-4 (dipeptidyl peptidase-4)
DPP-4 inhibitor + metformin group	DPP-4 inhibitor + metformin group	Beni-Suef University	marketed	DPP-4 inhibitor + biguanide combination	DPP-4 enzyme; metformin acts on multiple targets including mitochondrial glycerophosphate dehydrogenase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (DPP-4 inhibitor class)

Merck Sharp & Dohme LLC · 5 drugs in this class
Daewoong Pharmaceutical Co. LTD. · 4 drugs in this class
AstraZeneca · 4 drugs in this class
LG Life Sciences · 2 drugs in this class
Tanabe Pharma Corporation · 2 drugs in this class
Ain Shams University · 2 drugs in this class
Ono Pharmaceutical Co. Ltd · 2 drugs in this class
Cinnagen · 1 drug in this class
GRADE Study Group · 1 drug in this class
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). DPP-4 inhibitor (sitagliptin) — Competitive Intelligence Brief. https://druglandscape.com/ci/dpp-4-inhibitor-sitagliptin. Accessed 2026-05-17.

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