Who are Donepezil HCI (drug)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Neostigmine with glycopyrrolate, Neostigmine + Glycopyrrolate, Donepezil (Aricept), Neostigmine+Glycopyrronium, Placebo/Galantamine (Reminyl®), Neostigmine w/ Glycopyrrolate.

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Last reviewed 2026-05-16 · How we verify

Donepezil HCI (drug) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Donepezil HCI (drug) (Donepezil HCI (drug)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Acetylcholinesterase inhibitor. Area: Neurology.

marketed Acetylcholinesterase inhibitor Acetylcholinesterase (AChE) Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Donepezil HCI (drug) (Donepezil HCI (drug)) — Neurognostics. Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function in Alzheimer's disease.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Donepezil HCI (drug) TARGET	Donepezil HCI (drug)	Neurognostics	marketed	Acetylcholinesterase inhibitor	Acetylcholinesterase (AChE)
Neostigmine with glycopyrrolate	Neostigmine with glycopyrrolate	The Cleveland Clinic	marketed	Acetylcholinesterase inhibitor with anticholinergic agent	Acetylcholinesterase; muscarinic acetylcholine receptors
Neostigmine + Glycopyrrolate	Neostigmine + Glycopyrrolate	Merck Sharp & Dohme LLC	marketed	Acetylcholinesterase inhibitor with anticholinergic agent	Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (glycopyrrolate)
Donepezil (Aricept)	Donepezil (Aricept)	University of Virginia	marketed	Acetylcholinesterase Inhibitor	Beta-secretase 1, Multidrug resistance protein 1, Acetylcholine receptor subunit epsilon
Neostigmine+Glycopyrronium	Neostigmine+Glycopyrronium	Pusan National University Yangsan Hospital	marketed	Acetylcholinesterase inhibitor + Anticholinergic agent	Acetylcholinesterase; Muscarinic acetylcholine receptors
Placebo/Galantamine (Reminyl®)	Placebo/Galantamine (Reminyl®)	Ludwig-Maximilians - University of Munich	marketed	Acetylcholinesterase inhibitor	Acetylcholinesterase; nicotinic acetylcholine receptors
Neostigmine w/ Glycopyrrolate	Neostigmine w/ Glycopyrrolate	University of Texas Southwestern Medical Center	marketed	Acetylcholinesterase inhibitor with anticholinergic agent	Acetylcholinesterase (neostigmine); muscarinic acetylcholine receptors (glycopyrrolate)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Acetylcholinesterase inhibitor class)

Eisai Inc. · 2 drugs in this class
Ludwig-Maximilians - University of Munich · 1 drug in this class
Neurognostics · 1 drug in this class
Pontificia Universidade Catolica de Sao Paulo · 1 drug in this class
Second Affiliated Hospital of Wenzhou Medical University · 1 drug in this class
Shanghai Jiao Tong University School of Medicine · 1 drug in this class
Shanghai Mental Health Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Donepezil HCI (drug) — Competitive Intelligence Brief. https://druglandscape.com/ci/donepezil-hci-drug. Accessed 2026-05-16.

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