Who are DNase's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): recAP, Fabrazyme (agalsidase beta), rhDNAse, Pulmozyme®, Dornase alfa (Pulmozyme), Humia inj..

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Subscribe to /feed/ci/dnase.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-13 · How we verify

DNase — Competitive Intelligence Brief

DNase (DNase) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Recombinant enzyme. Area: Respiratory / Pulmonary.

marketed Recombinant enzyme Deoxyribonucleic acid (DNA) Respiratory / Pulmonary Small molecule Live · refreshed every 30 min

Target snapshot

DNase (DNase) — The Hospital for Sick Children. DNase is a recombinant deoxyribonuclease enzyme that breaks down extracellular DNA in viscous secretions, reducing mucus viscosity and improving airway clearance.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
DNase TARGET	DNase	The Hospital for Sick Children	marketed	Recombinant enzyme	Deoxyribonucleic acid (DNA)
recAP	recAP	AM-Pharma	marketed	Recombinant enzyme	Lipopolysaccharide (LPS) and pathogen-associated molecular patterns (PAMPs)
Fabrazyme (agalsidase beta)	Fabrazyme (agalsidase beta)	Genzyme, a Sanofi Company	marketed	Enzyme replacement therapy (ERT); recombinant enzyme	α-galactosidase A (GLA gene product); substrate: globotriaosylceramide (GL-3)
rhDNAse	rhDNAse	The Hospital for Sick Children	marketed	Recombinant enzyme	Extracellular DNA (deoxyribonucleic acid)
Pulmozyme®	Pulmozyme®	AO GENERIUM	marketed	Recombinant enzyme	Extracellular DNA
Dornase alfa (Pulmozyme)	Dornase alfa (Pulmozyme)	University of Jena	marketed	Recombinant enzyme	Extracellular DNA (deoxyribonucleic acid)
Humia inj.	Humia inj.	Huons Co., Ltd.	phase 3	Recombinant enzyme / Hyaluronidase	Hyaluronic acid (extracellular matrix component)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Recombinant enzyme class)

The Hospital for Sick Children · 2 drugs in this class
AO GENERIUM · 1 drug in this class
Fondation Ophtalmologique Adolphe de Rothschild · 1 drug in this class
Protalix · 1 drug in this class
University Hospital, Strasbourg, France · 1 drug in this class
University of Jena · 1 drug in this class
AM-Pharma · 1 drug in this class
University of Missouri-Columbia · 1 drug in this class

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Cite this brief

Drug Landscape (2026). DNase — Competitive Intelligence Brief. https://druglandscape.com/ci/dnase. Accessed 2026-05-13.

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