DHA-PQP and PQ starting on Day 42 — Competitive Intelligence Brief

DHA-PQP and PQ starting on Day 42 (DHA-PQP and PQ starting on Day 42) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antimalarial combination therapy. Area: Infectious Disease.

phase 3 Antimalarial combination therapy Plasmodium falciparum and Plasmodium vivax parasites; heme detoxification pathway; mitochondrial function Infectious Disease Small molecule

Target snapshot

DHA-PQP and PQ starting on Day 42 (DHA-PQP and PQ starting on Day 42) — Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. DHA-PQP and PQ are antimalarial combination drugs that work by disrupting parasite metabolism and preventing malaria transmission.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
DHA-PQP and PQ starting on Day 42 TARGET	DHA-PQP and PQ starting on Day 42	Fundação de Medicina Tropical Dr. Heitor Vieira Dourado	phase 3	Antimalarial combination therapy	Plasmodium falciparum and Plasmodium vivax parasites; heme detoxification pathway; mitochondrial function
IPTp-DP	IPTp-DP	Kenya Medical Research Institute	marketed	Antimalarial combination therapy	Plasmodium falciparum (malaria parasite)
Artesunate plus Amodiaquine	Artesunate plus Amodiaquine	Bernhard Nocht Institute for Tropical Medicine	marketed	Antimalarial combination therapy	Plasmodium falciparum (multiple parasite targets including heme detoxification pathway and DNA synthesis)
lumefantrine plus artemether	lumefantrine plus artemether	Centers for Disease Control and Prevention	marketed	Antimalarial combination therapy	Malaria parasite heme metabolism and hemozoin formation
WHO-recommended periodic presumptive treatment	WHO-recommended periodic presumptive treatment	University of Washington	marketed	Antimalarial combination therapy
Amodiaquine-artesunate (ASAQ)	Amodiaquine-artesunate (ASAQ)	Centers for Disease Control and Prevention	marketed	Antimalarial combination therapy	Plasmodium falciparum heme polymerase; artemisinin-derived endoperoxide bridge
Coadministered Artesunate plus Amodiaquine	Coadministered Artesunate plus Amodiaquine	Professor Anders Björkman	marketed	Antimalarial combination therapy	Plasmodium falciparum heme metabolism and protein synthesis

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antimalarial combination therapy class)

1. London School of Hygiene and Tropical Medicine · 4 drugs in this class
2. Kenya Medical Research Institute · 2 drugs in this class
3. University of Oxford · 2 drugs in this class
4. Centers for Disease Control and Prevention · 2 drugs in this class
5. University of Melbourne · 1 drug in this class
6. Bernhard Nocht Institute for Tropical Medicine · 1 drug in this class
7. University of Washington · 1 drug in this class
8. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado · 1 drug in this class
9. Medicines for Malaria Venture · 1 drug in this class
10. Professor Anders Björkman · 1 drug in this class